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Discussion on Using 5 day panacur and Ivermectrin at same time
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New Member:
kamib
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Posted on Monday, Jul 9, 2007 - 7:20 pm:
I know of a person that is intending to do a 5 day Panacur for parasites and inject Ivermectrin for lice at the same time. This person is a a vet tech (which I am not).
I'm curious if this is a safe (or even necessary) practice. I can't find any interaction information between the two products.
These are in pregnant ponies in last stages of pregnancy (guessed to be w/in 30 days of delivery). They're not underweight and don't really have any other problems.
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Moderator:
DrO
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Posted on Tuesday, Jul 10, 2007 - 7:39 am:
As far as I know there are no tests done looking at the safety of this issue Kami. Even if one felt the need to treat encysted strongyles in a horse with lice, I think I would go after the lice first then do the strongyles, after all the ivermectin gets many stages of encysted strongyle.
DrO
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Member:
ryle
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Posted on Thursday, Jul 12, 2007 - 11:16 am:
Dr. O,
Am I missing something? I haven't seen anything that says ivermectin kills encysted strongyles, just fenbendazole dosed like a powerpac and moxidectin?
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Moderator:
DrO
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Posted on Friday, Jul 13, 2007 - 8:00 am:
Hmmm....the problem may be with what you want to define as "encysted".
Horses ingest infective L3 (third stage) larvae that make their way to the large bowel and penetrate into the mucosa of the bowel wall. There they develop a sheath of mucous around them, which is the "cyst" in which they continue molting to L4 and L5 stages. L5 reemerges back into the lumen where they become tissue destroying adults. All stages of the larvae in the bowel wall are "encysted". The term has been used for the hypobiosed L4 larvae which do have a prolonged period of encystment. Neither ivermectin nor moxidectin kills the hypobiosed L4 stages of encysted small strongyles, which is suppose to be the advantage of the 5 day high dose fenbendazole treatment. However the avermectins do kill many of the other stages, including non-hypobiosed encysted L4 larvae. It should also be noted that some recent work has called into question the efficacy of the high dose fenbendazole treatment at least for some populations of small strongyles.
For more on all of this see the Parasites topic in the GI Disease section and the Anthelmintics topics in the Medication section.
DrO
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