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Discussion on Research Summary: MSM Associated with Decrease Oxidants in Jumping Horses
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Moderator:
DrO
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Posted on Wednesday, Nov 12, 2008 - 9:06 am:
Here is a fascinating study demonstrating a positive effect on exercising horses using MSM and vitamin C supplementation. When supplemented, exercise induced oxidative and proinflammatory chemicals were reduced post exercise. While the changes were significant the significance to the horse's health and performance is uncertain. It seems intuitive that any improvement in these numbers would be helpful but it remains uncertain that a measurable improvement will be seen.
DrO
Acta Vet Scand. 2008 Nov 7;50(1):45
The effect of methyl sulphonyl methane supplementation on biomarkers of oxidative stress in sport horses following jumping exercise.
Maranon G, Munoz Escassi B, Manley W, Garcia C, Cayado P, Sanchez de la Muela M, Olabarri B, Leon R, Vara E.
ABSTRACT: BACKGROUND: Exercise induces changes in several organs and tissues, and this process might be due to oxidative damage caused by free radicals and inflammatory mediators. Methyl Sulphonyl Methane, better known as MSM, is a naturally occurring sulphur compound with well-known antioxidant properties. On the other hand, Vitamin C is important in limiting free radical damage in the aqueous phase of the cell, and cellular vitamin C status may be linked to the mechanisms involved in quenching cellular reactive oxygen species. The aim of this study was to determine if supplementation with MSM and vitamin C could alleviate exercise-induced oxidative stress in horses undergoing jumping competition. METHODS: Twenty four jumping horses involved in competition were used. Horses were given the following three treatment diets: control (without supplementation), MSM 8 mg/kg, and combined supplements (MSM 8mg/kg + Vit-C 5mg/kg). EDTA blood samples were collected before exercise, upon arrived to the schooling area (control), and each week after last show. Nitric oxide, carbon monoxide, lipid hyDrOperoxides and the antioxidant enzymes, glutathione peroxidase, glutathione transferase and glutathione reductase, plasma levels were determined. RESULTS: Competition induced a significant increase in lipid peroxidation, nitric oxide and carbon monoxide. By contrary, reduced glutathione as well as antioxidant enzyme activities, were decreased. MSM administration significantly ameliorated all these exercise-related changes, and this effect was potentiated by Vit C reaching values in some of the parameters similar to those found before competition. CONCLUSIONS: These results suggest that jumping exercise could induce harmful effects on horses, probably due to an increase in oxidative damage and proinflammatory molecules. In addition, we have demonstrated that MSM could exert some protective effect on oxidative and inflammatory exercise-induced injury.
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Member:
mitma
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Posted on Wednesday, Nov 12, 2008 - 5:33 pm:
Thanks for the info Dr. O... I haven't been online with HA much in the past several weeks due to my work schedule and I logged on today specifically to look at the "supplement" stuff... the field of equine "nutraceuticals" is so VAST and, similar to human medicine/nutition, seems to be rich with lots of opinion and less objective science!
So, here's what I really gathered from this study... given that the study group who showed the greatest reduction in measures of "inflammatory mediators" received 8mg/kg of MSM and 5 mg/kg of Vit. C, it seems like most commercially available "combo" joint supplements out there fall short of reaching these dosing requirements...
One of the supplements that I use for some of my horses contains 2500 mg of MSM and 1000 mg of Vit. C per the maintenance dose, in addition to other things like glucosamine, chonDrOitin, yucca, and hyaluronic acid (https://www.majestys.com/flexha.php), but for a 500 kg (1100 lb) horse this study suggests providing 4000mg of MSM and 2500 mg of Vit. C! Yikes! Please let me know if I've miscalculated... Clearly, you can get commercially available individual "component" supplements... but most of us want something a bit more simple... you know, just one "pill" to take...
So, I guess my question here is this... is there data out there that shows dose response studies for joint supplements in equines?
Thanks!
Martha
P.S. I apologize if the answer in in your written material on HA, but I started reading "today's discussions" first after logging on today!
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Member:
mitma
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Posted on Wednesday, Nov 12, 2008 - 6:42 pm:
O.K., I just finished reading the "Arthritis treatment/nutriceuticals" section on HA... so, I kinda answered my own question... arghhh! Still, what seems to be missing are studies on combination therapy??? Just let me know if you have any other pearls to share on this topic; meanwhile, I (as well as many of us) continue to stimulate the economy with support for the unregulated supplement industry! 
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Moderator:
DrO
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Posted on Thursday, Nov 13, 2008 - 10:04 am:
As it is published Martha, I stick it in here. I have long bashed MSM because of the lack of detectable absorption as a whole molecule. It is rapidly broken down in the gut. Perhaps these big doses overcome this problem? It is one report and often I find such reports contradicted a year later so keep you eye on this.
DrO
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Member:
mitma
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Posted on Tuesday, Nov 18, 2008 - 4:49 pm:
Thanks Dr. O...
One of the other horsey things I "subscribe" to is www.thehorse.com, which has recently launched (in addition to their weekly newsletter), a weekly NUTRITION newsletter and when I read the most recent one I had to laugh... clearly one has to sell "advertising" to pay for certain services, etc..., and it would appear that OCD is funding this new educational resource for all of us!
https://www.thehorse.com/enews/topic/nutrition/11172008.html
The relevant fact is the $$$$ size of the supplement industry for horses and humans!
Martha
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