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  Discussion on Tendinitis new treatment by RGTA ( reGeneraTingAgents)
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Posted on Monday, Nov 19, 2001 - 4:00 am:

New french treatment with spectacular success
for tendonitis using RGTA ( CMDBS = carboxymethylbenzylamisde sulfonate dextrans )
Total quick recovery for french top standarbred.

Posted on Monday, Nov 19, 2001 - 8:02 am:

Hello Cornic,
There are currently no good studies yet published on the use of this product in the treatment of tendinitis in horses. This chemical has shown promising results in the healing of a number of types of wounds, though I cannot find one involving tendons.

One of the mechanisim of actions is it appears to slow the natural degradation process that is a part of every wound healing so regeneration happens quicker. This seemed to be one of the better reviews that I could find:

J Biomed Mater Res 1999;48(4):578-90
Carboxymethyl benzylamide sulfonate dextrans (CMDBS), a family of biospecific polymers endowed with numerous biological properties: a review.

Logeart-Avramoglou D, Jozefonvicz J.

Laboratoire de Recherches sur les Macromolecules, UMR CNRS 7540, Institut Galilee, Universite Paris XIII, 93430 Villetaneuse, France. logeart@ext.jussieu.fr

The functionalized dextrans termed carboxymethyl benzylamide sulfonate dextran (CMDBS) represent a family encompassing a wide range of polymers. These soluble macromolecular compounds, which are substituted with specific chemical functional groups, are designed to interact with living systems. By analogy with glycosaminoglycan heparin, a natural highly charged anionic polysaccharide that exerts a variety of biological effects, we postulated that CMDBS compounds also possess binding sites capable of specific interactions with biological constituents, depending on the overall composition of the polymer. The synthesis and heparin-like properties of these CMDBS have been extensively investigated. Thus, it appears that dextran derivatives can mimic the action of heparin in regard to its interactions with antithrombin and serine proteases involved in blood coagulation. Other derivatives interact with various components of the immune system or with adhesive proteins such as fibronectin in modulating the proliferation of Staphylococcus aureus. Because they are able to stimulate wound healing in various in vivo models, these polysaccharides may also constitute a family of tissue repair agents because of their protecting and potentiating effects with heparin binding growth factors. Moreover, dextran derivatives in contact with cells such as endothelial cells, smooth muscle cells, or tumoral cells can affect both cell proliferation and metabolism. It appears that these bioactive polymers are also efficient tools to investigate the precise mechanism of action of individual biological activities by contrasting their mode of action to that of heparin. In addition to their numerous biological properties and biospecificity, functionalized dextrans are relatively simple to manufacture and exempt of donor contaminant, which make them attractive in a variety of clinical applications.

DrO
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