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  Discussion on History of Uveitis in a Breeding Stallion
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New Member:
cmcrill

Posted on Wednesday, Feb 21, 2007 - 8:06 pm:

Would you recommend breeding to a stallion who is blind in one eye from uveitis? I am a human ophthalmologist and in our species, conceivably it could be an inherited problem via the HLAB27 antigen. Is there any evidence in horses for possible hereditary tendency for uveitis?
New Member:
153337

Posted on Wednesday, Feb 21, 2007 - 11:23 pm:

Here is what I found in PubMed, there is probably something more recent in some other vet journals. I didn't read all of Dr. O's article, maybe it mentioned it.
Amber

Anim Genet. 1988;19(4):417-25. Links
Evaluation of breed as a risk factor for sarcoid and uveitis in horses.

* Angelos J,
* Oppenheim Y,
* Rebhun W,
* Mohammed H,
* Antczak DF.

James A. Baker Institute for Animal Health, New York State College of Veterinary Medicine, Cornell University, Ithaca 14853.

The relationship between breed and the risk of developing sarcoid tumours or uveitis of unknown etiology was evaluated in a retrospective study of 16242 equine cases admitted between 1975 and 1987 to the New York State College of Veterinary Medicine Large Animal Hospital, and 3198 equine tissue samples sent to the New York State Veterinary Diagnostic Laboratory between 1977 and 1987. Of 120 sarcoid cases from the Large Animal Hospital, sarcoids were twice as likely to develop in Quarter Horses (odds ratio, OR = 1.8, P less than 0.05) relative to Thoroughbreds and less than half as likely to develop in Standardbreds (OR = 0.2, P less than 0.001) relative to Thoroughbreds. Similarly, of 376 sarcoid cases from the Diagnostic Laboratory, Quarter Horses had a significantly higher risk of developing sarcoid (OR = 2.0, P less than 0.001) relative to Thoroughbreds, while Standardbreds had a significantly lower risk of developing sarcoid (OR = 0.5, P less than 0.05) relative to Thoroughbreds. In the uveitis diagnosis category, Appaloosas had a significantly higher risk of developing uveitis (OR = 6.4, P less than 0.001) relative to Thoroughbreds, while Standardbreds had a significantly lower risk of developing uveitis (OR = 0.4, P less than 0.05) relative to Thoroughbreds.
Moderator:
DrO

Posted on Thursday, Feb 22, 2007 - 7:22 am:

Hello Connie,
Though the work is early there have been associations of recurrent uveitis and some major histocompatibility complexes of equine leukocyte antigens:

Equine Vet J. 2004 Jan;36(1):73-5.
Equine recurrent uveitis is strongly associated with the MHC class I haplotype ELA-A9.
Deeg CA, Marti E, Gaillard C, Kaspers B.
Institute of Animal Physiology, Ludwig-Maximilians-University, Munich, Germany.

This was the second (and more specific) finding with the first in 1998 and this potential association ignored for the last 9 years, at least in the research literature. I think the work is early and the meaning uncertain but perhaps you could have the stallion investigated for this MHC and make your decision from there? Other than the above referenced institution, I am uncertain where you could have this checked.
DrO
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