This is an archived Horseadvice.com Discussion. The parent article and menus are available on the navigation menu below:
HorseAdvice.com » Diseases of Horses » Lameness » Weakness, Exhaustion & Overheating » AnhiDrOsis & Deficient Sweating »
  Discussion on Has anyone tried One AC?
Author Message
Member:
scooter

Posted on Monday, Apr 2, 2007 - 7:02 pm:

The old girl (Flash) quit sweating a few summers ago, considering everything she does O.K. She usually will stand in front of the fan and I have never seen her overheat. When it's VERY hot I hose them down.

I got some One AC and started her on it a week ago, and was wondering if anyone had any experience with it.....good or bad?
Member:
annaspop

Posted on Monday, Apr 2, 2007 - 9:43 pm:

Diane, my first horse stopped sweating over a large part of his body. I started him on One AC a month before I gave him away. They knew his history and were fine with his "issues". They conditioned him for endurance that fall and winter and then he went to a woman who is eventing him. He has had no problems that I've been told of. She is aware that she has to be careful of him when it is hot and humid.
Margy
Member:
scooter

Posted on Monday, Apr 2, 2007 - 10:14 pm:

Margy, did he start sweating when you gave him the One AC?
Member:
annaspop

Posted on Tuesday, Apr 3, 2007 - 9:13 am:

I didn't have him when he started sweating normally, but he does now.
Margy
New Member:
benbern

Posted on Tuesday, Apr 3, 2007 - 10:15 am:

I have a horse in Arizona that stopped sweating last summer during the monsoon season. His temperature would go to 103-104 and his respiratory rate would go way up. It was a long difficult summer have to hose him down many time during the day. Some one had to be home. We got a letter from the water company to tell us our usage was very high and to check for any leak problems. lol I started using the One AC but toward the end of the season and thought it was working. My vet said the in Arizona some horses will stop sweating during the monsoons and start up sweating again when the humidity goes down, and that this may not happen again ever for the horse. I am not sure if the One AC was working or if it was just the DrOp in the humidity. I have heard about good results from One AC. This summer if we have the same problem I will find a place up north to board the horse.
Moderator:
DrO

Posted on Wednesday, Apr 4, 2007 - 8:16 am:

Hello All,
Run a search on the product name as it is a previously discussed subject. In my opinion there is no logic nor research to show One AC to be a effective product. Despite the product being well known, the incidence and effect of anhiDrOsis on the equine industry has not improved that I am aware of.

If you go to the One AC site they display a scientific paper that purports to show a benefit. However if you compare the columns displaying body temperature of the treated against the controls every week during the 8 week trial the control body temps are lower throughout the study. I believe they make an incorrect statement in the paper that it is lower in the treatment group. Though they found the sweating scores higher in the treated group, the treatment group started out the study (week 1) with 50% greater sweating scores. How the conclusion was made that there appears to be a benefit escapes me.

However there are successful management regimes for those early in the course of the disease, see the article for more on this.
DrO
Member:
scooter

Posted on Sunday, Jul 22, 2007 - 7:59 am:

The One AC has done nothing for my mare. Just thought I would add my experience. We had some blistering heat and humidity earlier and not a DrOp of sweat. She never seems to overheat tho.
Member:
mysi

Posted on Sunday, Jul 22, 2007 - 3:09 pm:

I tried One AC last summer when my horse stopped sweating and he did begin sweating again although I don't really think it had anything to do with the One AC. I say that because I started it the next day and he began sweating like 2 days later and this year it's happened again and I've been using it for almost 2 weeks and it's done nothing. Last year I think it was coincidence.

My vet now wants me to put him on venti-pulman (I have no idea if I spelled that correctly) for five days. Has anyone ever heard of that?
Member:
scooter

Posted on Sunday, Jul 22, 2007 - 4:13 pm:

Melissa, I have known horses on the ventripulam (sp) but it was usually for heaves. Are they putting him on it for the anhiDrOsis?
Member:
mysi

Posted on Sunday, Jul 22, 2007 - 7:51 pm:

Yes for anhiDrOsis. I had never heard of it before so when I looked it up it states its for breathing issues. My vet said they use it for anhiDrOsis and it usually stimulates the horse to sweat. My concern is side effects, as long as it is not harmful I'm willing to try it.
Member:
scooter

Posted on Sunday, Jul 22, 2007 - 8:00 pm:

HMMMM let us know how it turns out. The horses I have known on it have never had any side effects....but who knows.
Member:
mysi

Posted on Sunday, Jul 22, 2007 - 9:25 pm:

Yeah, it sounds strange but I may give it a shot after some research. She said it's commonly used with the show jumpers here with the same problem. I'll let you know how it turns out. She said acupuncture is another option but I'm really sceptical of that.
Member:
mysi

Posted on Saturday, Jul 28, 2007 - 7:38 pm:

Hey Diane, I tried the Ventipulmin today and WOW did he sweat. I gave him 12cc's (10cc's for regular sized horse) one hour before I rode and within 30 min his butt was sweaty. Then when I rode he was drenched. He seemed so happy and less exhausted, it was great. I am supposed to use it for five days and the vet thinks that he will sweat on his own after that. If not I'll have to keep him on it until it cools down here and that's in Oct-Nov. That stuff is awfully expensive ($225 a bottle). But it's well worth it. I am so relieved.
Member:
scooter

Posted on Saturday, Jul 28, 2007 - 7:55 pm:

Melissa that is surprising, let me know what happens when you take him off it in 5 days. I know it is expensive$$ but I guess if it works, well worth it.
Moderator:
DrO

Posted on Sunday, Jul 29, 2007 - 9:36 am:

I did find a prelimary study in using B adrenergic agonist (which is how Ventupilmin or the generic clenbuterol works) and if I read the meaning of "Isc" right they did not find it helpful.

If you would Mellissa post back here from time to time and let us know how your horse is doing and I certainly would be interested in any other reports of its use.
DrO
PS: Here is the report:

A preliminary study of the short circuit current (Isc) responses of sweat gland cells from normal and anhiDrOtic horses to purinergic and adrenergic agonists.
Wilson DC, Corbett AD, Steel C, Pannirselvam R, Bovell DL.
School of Life Sciences, Glasgow Caledonian University, Glasgow, UK.

The causal factors of equine anhiDrOsis have not yet been elucidated but defective electrolyte transport mechanisms in the gland are likely to be involved. To investigate this possibility, experiments were performed on cultured equine sweat gland epithelia from five free-sweating UK horses (3 intact males, 2 mares, aged 2-4 years) and from three free-sweating Singapore horses (1 intact male, 2 mares, aged 3-5 years) and three anhiDrOtic (Singapore) horses (1 intact male, 1 gelding, 1 mare, aged 3-6 years). Cultured cells from each animal were grown on permeable supports and loaded into Ussing chambers to quantify transepithelial resistance and agonist-induced electrolyte transport by the short circuit current (Isc) technique. Transepithelial resistances across the layers of cultured cells were not significantly different between cells from UK and Singapore free-sweating horses, but were significantly reduced in anhiDrOtic animals. Purinergic agonists added to the apical and basolateral aspects of the cultured cells caused similar increases in Isc between the two populations of unaffected cells, but Isc increases were significantly reduced in anhiDrOtic animals. Beta-adrenergic agonist stimulation of the anhiDrOtic cell layers failed to elicit any change in Isc. These pilot results not only confirm earlier conclusions from anatomical findings that failure in the secretory process occurs in anhiDrOsis but also indicate that both of the known ion transport mechanisms are involved. The trigger for these failures warrants further investigation.
DrO
Member:
mysi

Posted on Sunday, Jul 29, 2007 - 2:49 pm:

I will definitely keep you updated. I will say when I got to the barn this morning at 7am it was already like 90+ outside and we keep their fans off at night due to storms so it's stuffy in the barn. Moose was sweaty like he'd always been before he stopped sweating. The Ventipulmin only works for 6-8 hours, so I'm hoping that it worked and he'll continue to sweat on his own. I'm the eternal optimist.

My vet says that they have clients that use it every summer to kick start when their horses stop sweating, some who have to use it every summer all summer and some who use it every time they ride all year round. I hope to be the first.

I'll ask my vet here if she has any reports on the issue and I will let you know how Moose does. I've got my fingers crossed.
Member:
mysi

Posted on Wednesday, Aug 8, 2007 - 9:47 am:

Hello Dr. O & Diane,

Well, I went the 5 days and Moose sweat all five days wonderfully. The sixth day with no Ventipulmin he sweat a little in the beginning then stopped and a little more when we were on our post workout walk. The seventh day again with no Ventipulmin - no sweat at all. So I gave him a day off and have come to the conclusion that I will have to give it to him the days we work for his own well being. He went back on it and he does sweat alot while on it, so it definitely works. I am changing my exercise regimen to heavy workouts 4 days a week with the RX, and walking trail rides 2 days a week without. On the days without, I hose him before we ride and extensively after with fans too and he seems fine.

Now will he ever sweat on his own again? I have no idea. I will keep testing it as the weather changes, which is a long time from now down here!

He's still getting the ONE AC per my vets recommendation, but it's useless as far as I am concerned and when I run out I'm not getting more.
Member:
scooter

Posted on Wednesday, Aug 8, 2007 - 2:56 pm:

Thanks for the update Melissa, that is very interesting! I took my mare off the one AC also. She is retired and I don't work her so she handles the heat fine surprisingly. Good Luck with Moose I'm glad you found something that works$$$
Moderator:
DrO

Posted on Friday, Aug 10, 2007 - 12:35 pm:

Wow this is very interesting about the clenbuterol and am interested in any other experiences. Based on this and the lack of other good therapy I will include it in the article as an experimental therapy. It should be remembered anhiDrOsis is a progressive disorder and it still in unknown if this might slow down, speed up, or have no effect on the rate of progression.
DrO
Home Page | Top of Page | Join Us!
Horseadvice.com is a BBB Accredited Business. Click for the BBB Business Review of this Horse Training in Stokesdale NC