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Discussion on Blood serum antibody for eye ulcer
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Member:
Belhaven
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Posted on Friday, Jul 30, 2004 - 8:06 pm:
My 6yo has a small eye ulcer that my vet is treating with Gentak and Atropine. Since it was not responding as he liked he made eye DrOps from the horse's blood serum...
I realized that he did not say if the DrOps should be refrigerated. I started the DrOps yesterday and gave them again today.
I have been keeping them in a medicine cabinet-so they are at room temperature. Is this incorrect?
If so is he at risk that they were used today after NOT being refridgerated-should I discontinue use until I can contact my vet?
Also what is the success in treating an eye ulcer with this serum?
Thank you Dr O---once again your site is invaluable.
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Moderator:
DrO
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Posted on Saturday, Jul 31, 2004 - 12:29 pm:
Leah, I don't know so you should contact your veterinarian concerning refrigeration. Until then follow his instructions and don't refrigerate. I do not have experience with this treatment for indolent ulcers and there is very little scientific work on this. Initial reports suggest that it might be beneficial for slowing collagenase but no more so than the more standard and perhaps less expensive standard therapies. Much might depend on preparation and concentration of the proteins.
Is the eye not healing because repair has slowed or is it felt the ulcer is being propagated by active infection and collagenase?
DrO
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Member:
Belhaven
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Posted on Sunday, Aug 1, 2004 - 7:32 am:
Hello Dr O-here is what I learned in case someone else would like to know as well!
Ideally yes it should be kept cold, but my vet also felt the one day in a cool medicine cabinet wouldn't ruin it---so it is useable, just go ahead and refridgerate from now on.
I am nor quite sure why the eye was slow to heal...part of it might have been that I was not doing a good job of getting the ointment actually IN his eye, part could be (now this is just my idea-not necessarily that of my vets) is since birth this horse has never responded well to antibiotics...no matter what which antibiotic is used.
If he needs them, in my mind I know we will need 2-3 "series" before his body reacts...so maybe that was a factor.
Since using the serum DrOps his eye has finally started to show improvement-however I can't be sure if indeed it IS the DrOps as I also became more effective at getting the ointment in his eye( as opposed to over, under, around...LOL). Also it could just be taking this long for his body to react to the anitbiotic.
So I guess no real answer to this one--the vet is coming out tomorrow to check him and restain. I will post a follow up for archive purposes.
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Member:
sdms
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Posted on Tuesday, Aug 25, 2009 - 10:36 am:
Dr. O, I've read the article associated with this topic and found the recommendation of autologous serum as a part of anticollagenase therapy. Above you mentioned that in 2004 there had been little scientific work done regarding the use of serum for indolent ulcers. I'm wondering if there have been any additional studies on the use of serum for indolent ulcers since then.
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Moderator:
DrO
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Posted on Wednesday, Aug 26, 2009 - 1:55 am:
Hello SaraM,
There remains little in the way of scientific studies in horses and the articles recommendations are about all we have. In humans there has been a flurry of research primarily on autologous serum use in dry eye. There are some reviews and case studies but nothing we can really hang out hat on yet.
DrO
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Member:
sdms
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Posted on Wednesday, Aug 26, 2009 - 6:37 am:
Thanks, DrO.
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Member:
vickiann
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Posted on Wednesday, Aug 26, 2009 - 12:42 pm:
My daughter used this for one of her horses who had an ulcer with good results. He also has superficial keratitis, thought to be an autoimmune condition. Perhaps this blood serum remedy is used more often when autoimmune factors are considered part of the problem? Believe it was made by the eye specialists at University of Florida Veterinary School. She was told to refrigerate.
What ultimately did the most long term for her horse was a scraping of the eye with follow up ointment treatment. He has been stable requiring no on-going treatment for quite a while.
One of mine had an ulcerated cornea that was not responding to treatment on a time table satisfactory to my Veterinarian who at that point prescribed alternating between Gentak and a Triple Antibiotic (without steroid, of course) every two hours around the clock.
The atropine was used prior to the ointments for quite a long while and when the ulcer finally cleared it took a long time for the dilation of the eye to go back to normal.
But rotating the two different ointments and sticking to the very frequent administration healed the ulcer.
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