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Discussion on Research Summary: Tulathromycin (Draxxin®) Use in Lung Abscess
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Moderator:
DrO
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Posted on Monday, Jan 14, 2008 - 8:59 am:
This might be huge but does require some further study. In this study one small dose injection once a week of a widely available and affordable antibiotic was effective in curing lung abscesses of unknown etiology in foals! The work needs to be further studied for rhodococcus in particular but this looks very promising and may have other uses in the horse where a macrolide is indicated. For more see the article on Rhodococcus.
DrO
Vet J. 2007 Sep;174(2):418-21.
Evaluation of tulathromycin in the treatment of pulmonary abscesses in foals.
Venner M, Kerth R, Klug E.
Equine Clinic, University of Veterinary Medicine Hannover, Foundation, Bischofsholer Damm 15, Hannover D-30173, Germany.
Tulathromycin is a new injectable macrolide antibiotic used for the treatment of pulmonary diseases of swine and cattle. In this study, 37 foals with sonographic evidence of lung abscesses were treated with tulathromycin and 33 foals (group 2) with a combination of azithromycin once daily for the first seven days of therapy, thereafter every other day) and rifampin. The bacterial aetiological agent was not determined. The foals were only mildly sick and the median number of pulmonary abscesses was 1.4 (group 1) and 1.6 (group 2). Thirty foals in each group were treated without modifying therapy protocols until all clinical signs of disease had subsided. Tulathromycin was administered for a mean of 53 days, and azithromycin/rifampin for 42 days. The following side effects were associated with tulathromycin (279 IM injections): self-limiting diarrhoea in 11 foals; elevated temperature in six foals, and swellings at the injection site in 12 foals. This study provides some evidence that tulathromycin is well tolerated and appears promising for the treatment of pulmonary abscesses in foals.
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