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Discussion on Research Summary: Muscle injury (necrosis) following a bout of colic and endotoxemia
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Moderator:
DrO
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Posted on Friday, Jan 18, 2008 - 8:59 am:
We occasionally get reports of lameness problems following colic. Here is a report that might explain some cases of stiffness and lameness following a bout of colic. For more see the article on Rhabdomyolysis.
DrO
Vet Rec. 2007 Dec 8;161(23):786-9.
Myonecrosis in three horses with colic: evidence for endotoxic injury.
Valentine BA, Lohr CV.
Veterinary Diagnostic Laboratory, Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, or 97331, usa.
Three horses with colic, clinical evidence of endotoxaemia and high serum activities of creatine kinase and aspartate aminotransferase were examined postmortem. The horses were diagnosed with severe ulcerative colitis, pyloric ulceration and stenosis with colonic sand impaction, and colonic obstruction due to faecaliths. There was no gross or histological evidence of muscle trauma. Their semimembranosus muscles had scattered acute to subacute segmental necrosis of the myofibres, suggestive of endotoxin-induced muscle injury.
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