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Discussion on Aural plaques/ Aldara
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Member:
sbower
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Posted on Monday, Jan 28, 2008 - 10:50 pm:
Has anyone tried Aldara to treat aural plaques or sarcoids? Theres a clinical trial going on at the University of Minnesota. Since Aldara can be prescribed by any vet I'm wondering if anyones tried it?
Dr O any thoughts about how/why this medication might work?
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Moderator:
DrO
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Posted on Tuesday, Jan 29, 2008 - 8:48 am:
What is it Shelly?
DrO
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Member:
sbower
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Posted on Tuesday, Jan 29, 2008 - 6:01 pm:
Sorry, I should have provided a link. Its a prescription topical medicine called Aldara(Imiquimod) used for humans used to treat some types of warts, actinic keratosis, and superficial basal cell carcinoma.
www.aldara.com
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Moderator:
DrO
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Posted on Wednesday, Jan 30, 2008 - 6:54 am:
I found this one study on sarcoids and it would appear a little more work needs to be done to see if a dosage regimen might improve its cure rate. I would not expect aural plaques to improve with an up-regulating immunomodulatory drug, for more on this see the article Diseases of Horses » Skin Diseases, Wounds, and Swellings » Bumps / Nodules / Warts / Tumors » Overview of Bumps, Nodules, Warts & Tumors.
DrO
Vet Dermatol. 2006 Aug;17(4):259-65.
Efficacy of imiquimod 5% cream in the treatment of equine sarcoids: a pilot study.
Nogueira SA, Torres SM, Malone ED, Diaz SF, Jessen C, Gilbert S.
Veterinary Clinical Sciences Department, University of Minnesota, Saint Paul, Minnesota 55108, USA.
Imiquimod is an immune response modifier with potent antiviral and antitumour activity. The objective of this pilot study was to evaluate the efficacy of an imiquimod 5% cream (Aldaratrade mark: 3M, Saint Paul, MN, USA) as a topical treatment for equine sarcoids. Fifteen horses with a total of 19 tumours were enrolled, including mixed (7), fibroblastic (5), flat (3), verrucous (2), and nodular (2) types. Baseline data included history, physical examination, tumour location, measurement and digital photography. Imiquimod was applied by the owners three times a week until complete resolution of the tumour or 32 weeks, whichever occurred first. Tumours were measured and photographed every 4 weeks. Treatment efficacy was defined as 75% or greater reduction of tumour size by the end of the trial. Four sarcoids were withdrawn from the study. Twelve of the remaining 15 tumours (80%) showed more than 75% reduction in size and nine (60%) totally resolved between 8 and 32 weeks. The most common adverse effects of exudation, erythema, erosions, depigmentation and alopecia were limited to the tumour and adjacent areas. The results suggest that topical imiquimod is a therapeutic option for the treatment of equine sarcoids, although more detailed studies are required to corroborate these initial findings.
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