Site Menu:
This is an archived Horseadvice.com Discussion. The parent article and menus are available on the navigation menu below: |
HorseAdvice.com » Diseases of Horses » Lameness » Muscle & Tendon Diseases » Rhabdomyolysis: Tying Up, Shivers, PSSM, EPSM » |
Discussion on Research Study: New information on Atypical Myopathy | |
Author | Message |
Moderator: DrO |
Posted on Tuesday, Apr 22, 2008 - 9:03 am: Atypical myopathy is increasingly reported in both Europe and North America and the remains a mystery. Here is a big first step toward understanding this disease of thin to moderate condition young horses on pasture. It compares this condition with a rare genetic condition in humans called type 2 glutaric acidemia. This is a disease in which fat and protein are poorly utilized as energy sources. Management in humans is to feed low fat, low protein, high starch diets, just the reverse of most of our other equine myopathies. We will continue watching this issue very closely.DrO Neuromuscul Disord. 2008 Apr 10; Acquired multiple Acyl-CoA dehyDrOgenase deficiency in 10 horses with atypical myopathy. Westermann CM, Dorland L, Votion DM, Velden MG, Wijnberg ID, Wanders RJ, Spliet WG, Testerink N, Berger R, Ruiter JP, Kolk JH. Department of Equine Sciences, Medicine Section, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 114, 3508 TD Utrecht, The Netherlands. The aim of the current study was to assess lipid metabolism in horses with atypical myopathy. Urine samples from 10 cases were subjected to analysis of organic acids, glycine conjugates, and acylcarnitines revealing increased mean excretion of lactic acid, ethylmalonic acid, 2-methylsuccinic acid, butyrylglycine, (iso)valerylglycine, hexanoylglycine, free carnitine, C2-, C3-, C4-, C5-, C6-, C8-, C8:1-, C10:1-, and C10:2-carnitine as compared with 15 control horses (12 healthy and three with acute myopathy due to other causes). Analysis of plasma revealed similar results for these predominantly short-chain acylcarnitines. Furthermore, measurement of dehyDrOgenase activities in lateral vastus muscle from one horse with atypical myopathy indeed showed deficiencies of short-chain acyl-CoA dehyDrOgenase (0.66 as compared with 2.27 and 2.48 in two controls), medium-chain acyl-CoA dehyDrOgenase (0.36 as compared with 4.31 and 4.82 in two controls) and isovaleryl-CoA dehyDrOgenase (0.74 as compared with 1.43 and 1.61nmol min(-1)mg(-1) in two controls). A deficiency of several mitochondrial dehyDrOgenases that utilize flavin adenine dinucleotide as cofactor including the acyl-CoA dehyDrOgenases of fatty acid beta-oxidation, and enzymes that degrade the CoA-esters of glutaric acid, isovaleric acid, 2-methylbutyric acid, isobutyric acid, and sarcosine was suspected in 10 out of 10 cases as the possible etiology for a highly fatal and prevalent toxic equine muscle disease similar to the combined metabolic derangements seen in human multiple acyl-CoA dehyDrOgenase deficiency also known as glutaric acidemia type II. |