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| Discussion on Alopecia areata or pemphigus foliciaceus | |
| Author | Message |
| New Member: shaza |
Posted on Friday, Jun 27, 2008 - 7:13 am: HelpMy horse has an odd skin problem thats been going on for months now and is getting worse.My vets are really at a loss.They suspect Alopecia Areata but her sympstoms or signs of this are not normal. This is her Histolgy report followed by some pictures.She is currently on 100 steriod tablets a day,fuciderm cream applied twice daily,hibiscrub twice daily and broad spectrum antibiotics but at the moment there is no change.Any ideas? She currently has a 3 week old at foot. The way things are going at the moment we are just making her comfortable until foal old enough to be weaned and then she going to be put to sleep,but obviously i`d rather not to it.Her breathing is being affected as her nostirls are closing in and her lymph nodes are very swollen. Clinical information: At 9 months gestation developed alopecia on face,swelling of skin on face,and nodules between mandibles. Negative for ringwrom and parasites. Bloods at 9 months gestation normal. No respose to antibiotics and NSAIDs. Foalled normally. Has now gotten worse. Include biopsies from cheek and muzzle. Aspirate from nodules between mandibles. Macroscopic description 1) 2 grey skin punch biopsies 6mm bisected. Cut section pale and grey. Skin fragment embedded whole. 2) Scabby grey skin punch biopsies,6mm. Bisected,cut section pale. Microscopic description: Haired skin, 1 and 2  bscuring the superficial dermis to the deep and lateral margins are myriad macrophages,lymphocytes,plasma cells and occasional neutrophils with rare multinucleated giant cells. Mulitfocally follicular epithelial sheaths are infiltrated and destroyed by neutrophils and lymphocytes, with pools of dengerate neutrophils within the intact lumen. Focally there is a 100 x 300 um fragment of material with numerous oblique PAS postive octagonal components, each with an indidvidual central pore (plant material,PRESUMPTIVE) within the mid-dermis. The overlying epidermis is moderatley to markedly hyperpalstic with multifocal ulceration. Ulcerated regions are infiltrated by myriad degenerate neutrophils within an eosinophilic martix(serosuppurative crusts). Entrapped with these crusts are variably sized colonies of gram postive cocci. There is multifocal parakeratotic hyperkeratosis.. Examination of cytology preps reveal normal blood [IMG]https://i37.photobucket.com/albums/e78/shazgeoff/variouspicsofhorses190.jpg[/IMG] [IMG]https://i37.photobucket.com/albums/e78/shazgeoff/variouspicsofhorses203.jpg[/IMG] |
| Moderator: DrO |
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| New Member: shaza |
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| Moderator: DrO |
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| New Member: shaza |
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