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  Discussion on Collagen Type 5
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New Member:
davidb

Posted on Monday, Aug 25, 2008 - 11:59 pm:

I do not know if this is the best location for the question. In which Equine Chromosome would the human Col5a (1&2) genes most likely be found? They are involved in the synthesis of Type 5 collagen and are implicated in Ehlers-Danlos Type 1 and 2. Any ideas? Any ideas where to go to get this answer? Thanks David
Moderator:
DrO

Posted on Wednesday, Aug 27, 2008 - 6:49 am:

Welcome David,
I believe the initial stages of mapping of the horse genome is completed and the order of the base pairs well placed. But if I understand the current status of the mapping project (see following summary), the genes and associated genomes themselves have not been completely mapped just the DNA markers used to create the sequencing. It may be that this information about a specific gene or genome is not yet available. Here is some interesting information on the current status of the map and perhaps the email address of someone who could provide you with this information if available.
DrO

The horse genome derby: racing from map to whole genome sequence.
Chowdhary BP, Raudsepp T.
Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX, 77843-4458, USA. bchowdhary@cvm.tamu.edu

The map of the horse genome has undergone unprecedented expansion during the past six years. Beginning from a modest collection of approximately 300 mapped markers scattered on the 31 pairs of autosomes and the X chromosome in 2001, today the horse genome is among the best-mapped in domestic animals. Presently, high-resolution linearly ordered gene maps are available for all autosomes as well as the X and the Y chromosome. The approximately 4350 mapped markers distributed over the approximately 2.68 Gbp long equine genome provide on average 1 marker every 620 kb. Among the most remarkable developments in equine genome analysis is the availability of the assembled sequence (EquCab2) of the female horse genome and the generation approximately 1.5 million single nucleotide polymorphisms (SNPs) from diverse breeds. This has triggered the creation of new tools and resources like the 60K SNP-chip and whole genome expression microarrays that hold promise to study the equine genome and transcriptome in ways not previously envisaged. As a result of these developments it is anticipated that, during coming years, the genetics underlying important monogenic traits will be analyzed with improved accuracy and speed. Of larger interest will be the prospects of dissecting the genetic component of various complex/multigenic traits that are of vital significance for equine health and welfare. The number of investigations recently initiated to study a multitude of such traits hold promise for improved diagnostics, prevention and therapeutic approaches for horses.
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