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  Discussion on Research Summary: Adipose Derived Mesenchymal Stem Cell
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DrO

Posted on Wednesday, Sep 24, 2008 - 12:26 pm:

Yet another variation on a theme where mesenchymal stem cells derived from the lame horse's belly fat (adipose) are grown and injected back into the defect. Whether this allographic procedure might be easier than that derived from bone marrow is uncertain. The results were good but without lesion matched controls conclusions are difficult to make.
DrO

Vet Res Commun. 2008 Aug 6;

Equine adipose-tissue derived mesenchymal stem cells and platelet concentrates: their association in vitro and in vivo.

Del Bue M, Ricco S, Ramoni R, Conti V, Gnudi G, Grolli S.

Department of Animal Health, Veterinary Biotechnology, Food Quality and Safety, University of Parma, via del Taglio 8, 43100, Parma, Italy.

Equine mesenchymal stem cells (MSC) are of particular interest both for basic research and for the therapeutic approach to musculoskeletal diseases in the horse. Their multilineage differentiation potential gives them the capability to contribute to the repair of tendon, ligament and bone damage. MSCs are also considered a promising therapeutic aid in allogeneic cell transplantation, since they show low immunogenicity and immunomodulating functions.Adipose tissue-derived adult equine stem cells (AdMSC) can be isolated, expanded in vitro and then inoculated into the damaged tissue, eventually in the presence of a biological scaffold. Here we report our preliminary experience with adipose-derived mesenchymal stem cells in allogeneic cell-therapy of tendonitis in the horse. MSCs, derived from visceral adipose tissue, were grown in the presence of autologous platelet lysate and characterized for their differentiation and growth potential. Expanded AdMSC were inoculated into the damaged tendon after their dispersion in activated platelet-rich plasma (PRP), a biological scaffold that plays an important role in maintaining cells in defect sites and contributes to tissue healing. Fourteen out of sixteen treated horses showed a functional recovery and were able to return to their normal activity.
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