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Discussion on Research Summary: Surpass (topical diclofenac) and Arthritis
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Moderator:
DrO
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Posted on Friday, Nov 14, 2008 - 9:18 am:
Disappointing news as this piece of research throws the use of Surpass for arthritis in doubt. But this is not too surprising as my associate has tried using it on a arthritic hock and did not feel response was as good as a bit of bute.
DrO
J Vet Pharmacol Ther. 2008 Dec;31(6):554-61.
Liposome-based diclofenac for the treatment of inflammation in an acute synovitis model in horses.
Schleining JA, McClure SR, Evans RB, Hyde WG, Wulf LW, Kind AJ.
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USA. jschlein@iastate.edu
Lameness as a result of joint disease is a major source of decreased athletic performance in the horse. Most treatment protocols include the administration of nonsteroidal anti-inflammatory drugs (NSAIDs). Phenylbutazone, alone or in combination with other treatments, is the most commonly and widely used NSAID, however it has the potential for serious side effects. The introduction of the liposome-based formulation of the NSAID diclofenac has shown promising effect as a safe and convenient treatment for lameness associated with osteoarthritis. The purpose of this study was to evaluate the effect of topical liposome-based diclofenac in an acute inflammation model using subjective lameness scores and objective lameness evaluation, carpal surface temperature and circumference, synovial fluid cell count and total protein content, and the biochemical markers interleukin-1 (IL-1), IL-6, and prostaglandin E(2) as determinants of inflammation. In this acute inflammation model, there was no overall difference between treatment and control groups.
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Member:
sondra
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Posted on Tuesday, Dec 9, 2008 - 8:22 pm:
Bummer. I had just finished reading this:
https://www.horseadvice.com/horse/messages/5/283015.html
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Member:
ekaufman
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Posted on Tuesday, Dec 9, 2008 - 9:16 pm:
I saw no positive effect in all 3 horses I tried to treat with Surpass. BUT it did give some relief to the OA in my broken hand when I applied it without gloves. Note that my vet bawled me out big time for giving myself horse doses of diclofenac. I'm also human, hence suggestible....
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Member:
sondra
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Posted on Tuesday, Dec 9, 2008 - 9:51 pm:
I know many people - all horse peeps - who use it successfully on their own arthritis and carpel tunnel! Perhaps it'd work better on equines if we clipped the area first... just a thought.
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Member:
dres
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Posted on Tuesday, Dec 9, 2008 - 11:01 pm:
I clipped hock and tendon areas ,, no change at all.. but my hands did feel better. ! Its to expensive for me to try any more..
On the first day God created horses, on the second day he painted them with spots..
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Member:
canter
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Posted on Wednesday, Dec 10, 2008 - 7:27 am:
After investing in 2 tubes of Surpass, I also concluded it made no difference in the horse. Since I really rubbed it in and was generous with how much I used, I don't think the hair got in the way. It was my barn manager that busted me for not wearing gloves and I too got a scolding...
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