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  Discussion on Research Summary: Lawsonia intracelularis Study
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DrO

Posted on Thursday, Dec 18, 2008 - 9:10 am:

Here is a great review of 57 cases found within a two year period. The late summer to early winter time frame is particularly interesting since we understand little about the transmission of this disease. Of course this could reflect the age predelection of foals 4 to 8 months of age and the fact most are born in late winter and early spring.
DrO

J Vet Intern Med. 2008 Sep-Oct;22(5):1243-8.
Lawsonia intracellularis infection in horses: 2005-2007.
Frazer ML.
Hagyard Equine Medical Institute, Lexington, KY, USA.

BACKGROUND: Lawsonia intracellularis is an emerging equine pathogen that is a cause of equine proliferative enteropathy (EPE). OBJECTIVE: To describe the signalment, month of presentation, common clinical signs, clinicopathologic values, diagnostic tests used, antimicrobial use, and survival status in horses affected with EPE; to evaluate how affected horses sold at public auction as yearlings; and to determine results of fecal polymerase chain reaction (PCR) and serum immunoperoxidase monolayer assay (IPMA) results in age matched, clinically normal herdmates. ANIMALS: The study group was 57 horses treated for disease associated with L. intracellularis infection between August 2005 and January 2007. METHODS: Retrospective study examined horses exhibiting evidence of infection with L. intracellularis and testing positive for fecal PCR or serum IPMA. RESULTS: Horses ranged in age from 2 to 8 months with a median age of 6 months, and all were examined between August and January. Ventral edema was present in 81% of horses and hypoalbuminemia occurred in all horses. Only 50% of horses tested positive on both PCR and IPMA. Ninety-three percent of horses survived, and survival was unrelated to antimicrobial administered. Affected horses sold as yearlings an average of 68% less than other yearlings by the same sire. Age matched, clinically normal herdmates also tested positive for L. intracellularis on fecal PCR (6%) and IPMA (33%). CONCLUSION: L. intracellularis infection should be considered in young horses with ventral edema and hypoalbuminemia that are examined between August and January. Both fecal PCR and serum IPMA are needed to help determine disease status. Treated animals usually survive, although they do not sell for as high a price at public auction as other yearlings by the same sire. Age matched, clinically normal herdmates also test positive for L. intracellularis on fecal PCR and serum IPMA.
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