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  Discussion on Tildren administration
Author Message
New Member:
andiesue

Posted on Sunday, May 17, 2009 - 2:23 pm:

Hi, My 8yr Thoroughbred has been diagnosed with navicular and I am planning on treating him with Tildren. I was wondering what the best way to administer Tildren is. My daughter, a DVM (albeit small animal)has gotten FDA approval and it's on its way from France. My local farm vet will be administering it.(He's never even heard of it) My daughter's research stated that it's 1 mg/kg Bwt over a 10 day period. But I have also heard of giving it over a shorter time period, with one vet giving it all in one day. I know that increases the risk of colic and I sure don't want that. On the other hand, it would be much simpler for everyone involved if we could shorten the duration. Any thoughts on this?
Thank you,
Andie
P.S. This is my first time using your website and I hope I have done this right! :-)
Member:
dres

Posted on Sunday, May 17, 2009 - 2:37 pm:

Welcome Andrea,.. Boy I sure would not be messing with something like this unless I had a competent vet that knew what he / she was doing ..
To risk colic? that would be at the bottom of my inconvenient things to do as well..

good luck.. I am sure you will get the answer you are looking for..

On the first day God created horses, on the second day he painted them with spots. .
New Member:
andiesue

Posted on Monday, May 18, 2009 - 9:45 am:

Thanks Ann,
I do have the option of taking my horse over to my regular vet. It's 1 1/2 hours though, and she doesn't have a clinic yet, so I would have to haul everyday. So again, I was wondering if the treatment could be shortened to say, 5 days, and still be safe?
Andie
Moderator:
DrO

Posted on Monday, May 18, 2009 - 10:32 am:

Welcome Andrea,
We have not seen reports of colic at the one dosage. (NOTE addendum below.) As this has been a much discussed topic in Horseadvice recently we have just published an article on Tildren use in horses including the dosage rate and you will find it at Treatments and Medications for Horses » Miscellaneous Drugs » TiluDrOnate (Tildren and Skelid) Use in Horses.
DrO
Member:
kerrief

Posted on Monday, May 18, 2009 - 3:46 pm:

Hi Andrea,

My mare was treated with Tildren this past November. My vet administered the drug using a technique called limb profusion. This technique is safer, the drug goes to the targeted area and is done in about one hour per foot.Side effects, such as colic and heart issues are greatly reduced.

My mare did well, and did not suffer from any side effects. We treated both front feet. One foot one day, the other a week later.
Moderator:
DrO

Posted on Tuesday, May 19, 2009 - 8:48 am:

Hi Kerre,
I would note that side effects have not been reported in horses at the dosages and dosage rate given in the article and a limb perfusion technique has not been studied so even more experimental that the IV use is. It makes some sense but not clearly an improved technique. It may also be more prone to some complications like extravasation of the treatment.
DrO
Member:
kerrief

Posted on Tuesday, May 19, 2009 - 11:38 am:

Hello again,

One of the many benefits of having a forum like this is to gather information, relate experiences and brainstorm with others. With that in mind, I'd like to add this to our discussion.

Before I agreed to treating my mare with Tildren, I researched the drug, especially information from Europe, as the drug has a longer history of use there.

Information I obtained from a variety of sources mentioned colic as a possible side effect, as well as sweating and muscle twitching. In addition, the drug should be used with caution with horses that have cardiac/hypocalcaemic concerns.

This is one of the links:

https://www.georgevetgroup.co.uk/equine
/TILDRENfactsheet.pdf

Here is another good link.
https://www.vssco.co.uk/docs/TildrenNOAH.doc

Kerrie
New Member:
andiesue

Posted on Tuesday, May 19, 2009 - 5:30 pm:

Thank you everyone for their input and thanks especially to you, Dr. O for leading me to the correct dosage. What a wonderful website this is!
Andie
Moderator:
DrO

Posted on Wednesday, May 20, 2009 - 9:09 am:

You are welcome Andrea.

And thank you for the additional information Kerrie. The second reference above puts forth colic as a reported adverse reaction with a rate of 11% which is associated with more rapid administration rate. I have included this information in the article along with the whole of the treatment information sheet.
DrO
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