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Discussion on Research Summary: Previous EHV4 infection may be protective against EHV1 infection
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Moderator:
DrO
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Posted on Thursday, Dec 9, 2010 - 8:42 pm:
EHV4, a relatively mild upper respiratory infection, has been shown to induce a cross protective immunity to the potentially more severe EHV1 infections that are responsible for herpes myeloencephalitis and abortion. How protective this immunity is and how we use this information I am not sure. Possibly the development of a modified live virus EHV4 vaccine might now be indicated.
DrO
J Vet Med Sci. 2010 Dec 6.
Induction of a Th-1-Biased IgG Subclass Response against Equine Herpesvirus Type 1 in Horses Previously Infected with Type 4 Virus.
Bannai H, Tsujimura K, Kondo T, Nemoto M, Yamanaka T, Sugiura T, Maeda K, Matsumura T.
Epizootic Research Center, Equine Research Institute, Japan Racing Association.
Abstract
An immunoglobulin G (IgG) subclass response against equine herpesvirus type 1 (EHV-1) infection was investigated in horses that were naïve to EHV-1/4 and those that had previously been exposed to EHV-4. The IgG subclass response was determined by an ELISA using EHV-1-specific recombinant G protein as an antigen. In most horses naïve to EHV-1/4, IgGa, IgGa, and IgG(T) were induced after experimental infection with EHV-1. In contrast, a subclass response dominated by NIgGa and IgGb, with no apparent increase in IgG(T), was observed after EHV-1 infection in horses previously infected with EHV-4. Horses naturally infected with EHV-1 in the field showed similar responses. These results indicated that pre-infection with EHV-4 induced a Th-1-biased IgG subclass response against subsequent EHV-1 infection.
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Member:
mrose
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Posted on Thursday, Dec 9, 2010 - 9:26 pm:
Interesting. I enjoy reading your updates and find them interesting. Thanks for posting them.
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