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  Discussion on Kunjin virus disease
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DrO

Posted on Friday, Apr 15, 2011 - 7:35 am:

For our Australian members in New South Wales [NSW], Victoria, and South Australia, here is a cautionary warning. While it seems uncertain that this virus is causing the neurological signs it seems associated with a rise of Kunjin virus cases in humans.
DrO

Date: Thu 31 Mar 2011
Source: Australian Veterinary Association) Media Release

The AVA [Australian Veterinary Association veterinarians] are warning horse owners to take precautions against mosquito borne disease, as veterinarians report a growing number of horses with unusual neurological signs in New South Wales [NSW], Victoria, and South Australia. "These cases are still under investigation, however, they may result from infection with a mosquito borne virus in the Kunjin-West Nile group," said Dr Christine Smith, president-elect of the Equine Veterinary Association.

"Clinical signs may include depression and mild colic. These may also include the onset of neurological signs including increased responsiveness to touch and sound, facial paralysis, and difficulty masticating, hypermetria in forelimbs and weakness in hindquarters, general ataxia, and/or recumbency. Most of the horses involved appear to be recovering slowly, however there have also been reports of a few deaths," said Dr Smith.

The NSW Department of Industry and Investment requests bloods samples (serum and heparin) be submitted to the relevant laboratory, and follow up blood samples at 7 days and 3 weeks after the onset of clinical signs. All of the horses tested by the NSW Department of Industry and Investment so far have been negative for hendravirus, however veterinarians should follow PPE [personal protective equipment] protocols when examining sick animals.

There are a range of products available including fly veils and registered chemical treatments to help protect horses from insect bites. It is also advisable to try to keep horses inside during dawn and dusk to help reduce their exposure to mosquitoes. If a horse is exhibiting these clinical signs the owner should consult a veterinarian immediately.



Kunjin virus disease from New South Wales governmanet.

What is Kunjin virus disease?
Kunjin virus disease is a viral infection caused by a flavivirus (Kunjin virus) found in mainland Australia and Papua New Guinea. It is closely related to West Nile virus which is found in Africa, Europe and the USA. The virus is spread by the bite of certain mosquitoes.

What are the symptoms?
The vast majority of infections do not show symptoms. A small number of people develop mild illness with fever, enlarged lymph nodes, rash, swollen and aching joints, headache, muscle weakness and fatigue. Some people with Kunjin virus disease may develop encephalitis, a severe brain infection which may require hospitalisation.

How is it spread?
The virus is spread by the bite of the common banded mosquito, Culex annulirostris. This mosquito breeds in fresh water and tends to be found in spring, summer and autumn around natural wetlands and irrigation waters. The mosquito is especially common around the Murray Darling River basin areas in NSW during summer and into autumn. This mosquito tends to be most active after sunset and around dawn.

Kunjin virus is a virus of birds. Various water bird species are thought to be infected with the virus, although other animals such as horses can also become infected. Mosquitoes become infected by feeding on infected birds and possibly other animals. An infected mosquito can then bite a human and transmit the infection.


Who is at risk?
As some mosquitoes may carry the Kunjin virus, people who are bitten by mosquitoes are most at risk. People working, living or visiting areas of rural NSW where there are rivers, wetlands, flooded areas or heavily irrigated areas may be at greater risk of Kunjin virus infection because the mosquitoes are more likely to be infected from water birds that naturally carry high levels of virus.
Kunjin virus is more common in some parts of northern Australia.
NSW Health has established a several flocks of sentinel chickens around the state. During the mosquito season, the chickens are tested weekly for the mosquito-borne diseases (Kunjin and Murray Valley encephalitis viruses). New infections in chickens serve as an early warning that local mosquitoes in the area may be carrying the virus. Kunjin virus has been found on several occasions in the chicken sentinel flocks and in mosquitoes in NSW. Mosquitoes are also trapped, counted and tested for Kunjin virus.


How is it prevented?
Avoid being bitten by mosquitoes. Mosquitoes that carry Kunjin virus are usually most active in the hours after sunset and again around dawn.

•When outside cover up as much as possible with light-coloured, loose-fitting clothing and covered footwear.
•Use an effective repellent on all exposed skin. Re-apply repellent within a few hours, as protection wears off from perspiration, particularly on hot nights. The best mosquito repellents contain Diethyl Toluamide (DEET) or Picaridin.
•The stronger the concentration of an insect repellent, the less frequently it will need to be applied to stop mosquito bites. Repellents containing low concentrations of DEET or Picaridin provide shorter periods of protection and need to be reapplied more frequently so it's important to read the product information.
•Topical repellents are not recommended for use on children under 3 months. Use of physical barriers such as netting of prams, cots and play areas is preferred. Repellents containing less than 10% DEET or Picaridin are safe for older children if applied according instructions. Parents or carers should apply repellent.
•Light mosquito coils or use vapourising mats indoors. Devices that use light to attract and electrocute insects are not effective.
•Cover all windows, doors, chimneys, vents and other entrances with insect screens.
•When camping, use flyscreens on caravans and tents or sleep under mosquito nets.



How is it diagnosed?
Blood tests can show whether there are antibodies to Kunjin virus. Blood samples are taken while the person is unwell and then again two weeks later to see if there has been a change in the antibody levels. This can indicate that there has been a recent Kunjin virus infection.


How is it treated?
Treatment is supportive - there is no specific treatment for Kunjin virus disease.

What is the public health response?
When laboratories confirm Kunjin virus disease, they notify their local public health unit. Public health units follow up each case to determine where the person acquired the infection and assess if there is an ongoing public health risk.
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