This is an archived Horseadvice.com Discussion. The parent article and menus are available on the navigation menu below:
HorseAdvice.com » Diseases of Horses » Lameness » Diseases of the Hoof » Founder & Laminitis » Founder & Laminitis an Overview »
  Discussion on Research Summary: Exercise and Laminitis
Author Message
Moderator:
DrO

Posted on Sunday, Jul 14, 2013 - 8:02 am:

Such studies remain tentative (note the word putative in the conclusion) in there conclusions but I must say over the years pasture associated founders were more common in the inactive horse population than the active one.
DrO

Equine Vet J. 2013 Jul 2.
The effect of exercise on plasma concentrations of inflammatory markers in normal and previously laminitic ponies.
Menzies-Gow NJ, Wray H, Bailey SR, Harris PA, Elliott J.

Royal Veterinary College, London, UK.
Abstract

The mechanisms underlying predisposition to pasture-associated laminitis remain unclear; chronic inflammation is implicated and this may be exacerbated by physical inactivity.

OBJECTIVES:
To determine whether exercise affects the inflammatory profile of normal and previously laminitic ponies.

METHODS:
The short (1 day) and longer term (14 days) effects of low intensity (10 min walking and 5 min trotting) exercise on plasma inflammatory marker concentrations in normal (NL) and previously laminitic (PL) non-obese ponies (n = 6/group) was determined. Plasma concentrations of TNF-α, serum amyloid A (SAA), haptoglobin, insulin, adiponectin and fibrinogen were assayed by validated/standard methods. Data were analysed using a linear mixed effect model.

RESULTS:
Pre-exercise, plasma [adiponectin] was significantly (p = 0.0001) lower in PL (mean ± s.d. 2.4 ± 0.1ng/L) compared to NL (4.03 ± 0.2 ng/L), but exercise had no effect. Previous laminitis and exercise had no effect on plasma [TNF-α] or [fibrinogen]. SAA concentrations in all ponies were significantly (p = 0.00001) reduced after longer term exercise compared to day one values. Plasma [haptoglobin] was significantly (p = 0.00001) higher in PL compared to NL on Day one. This difference was no longer apparent after longer term exercise, such that [haptoglobin] in PL had decreased to concentrations similar to NL. Following short-term exercise, all ponies had an initial decrease in serum [insulin] immediately after exercise, followed by an increase peaking 10 min after exercise cessation, before returning to pre-exercise values. On Day 14 these fluctuations were significantly (p = 0.001) reduced in all ponies.

CONCLUSIONS:
Fourteen days of low intensity exercise significantly decreased [SAA] in all ponies and plasma [haptoglobin] in PL such that it was no longer increased compared to NL. Regular low intensity exercise appears to have an anti-inflammatory effect, which is possibly greater in PL, and so may be beneficial in reducing this putative risk factor in pasture-associated laminitis.
Home Page | Top of Page | Join Us!
Horseadvice.com is a BBB Accredited Business. Click for the BBB Business Review of this Horse Training in Stokesdale NC