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Discussion on Non healing lower leg wound
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New Member:
mhorse3
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Posted on Saturday, Aug 20, 2016 - 4:46 pm:
Hi Dr O,
I have read through most of your articles pertaining to this subject and many others for that matter but still would like your opinion. This is a long complicated story so i will be as brief as possible. On Feb 4th of this year my horse caught his leg in a wire fence and lacerated his lateral digital extensor at the level where it connects with the long digital extensor. 60% tear. Vet called. Cleaned and bandaged. told 2 months stall rest 2 months no riding. Vet came and redid bandage regularly. March 2nd bandage removed and hyDrOtherapy began. March 4th Anicell tendon graft applied. Leg wrapped. March 9th bandage removed. 3 hours later i went to check on horse and he had been chewing on wound and there was blood everywhere. I put a light wrap on wound as directed by vet and continued with hyDrOtherapy. March 11th i noticed his coronary band was red and inflamed. Vet called. By the time the vet arrived the inflammation had subsided. Vet reapplied Robert Jones bandage and continued to do so until March 29th i removed drsg. Wound was stinky, oozy and awful looking. Vet wanted me to cold hose and possibly keep him tied up so he couldn't get to wound. I sought a second opinion. Brought to a Board certified surgeon that specializes in wounds on April 4th. Wound was x-rayed and debrided down to bone. Left at clinic for a week. Brought home and was doing regular drsg changes. April 27th Local vet(#3) was out giving annual shots and convinced me to let him laser the wound. Said it would help it heal 10 times faster. Cleared with surgeon vet. Laser treatment done. Wound became very inflamed, reddened and painful. Brought back to surgeon vet May 12th. wound was double the size and angry. He thought the laser had burned wound. Left at clinic until June 23rd. He had done a skin graft and the wound was healing very nicely so I took horse home and at the next dsg change when i took the bandage off the wound was inflamed and angry. Started on steroid cream. Since then it gets better then gets inflamed again. He is currently on antibiotics and steroids. A couple weeks ago he finally got to come off stall rest. That didn't seem to make any difference but after a week it got inflamed again and he doesn't do more than a walk. He had broken out in hives and the vet thinks that had something to do with it.
Vet says he has never seen anything like it in all his years of treating wounds. He wonders if the tendon graft isn't the root of his problems.
We have kept the wound bandaged because this vet thinks it is the way to go and thinks hyDrOtherapy is old school and also anytime the bandage is not on the horse wants to bite it.
I am very interested in your thoughts on what is going on. Ever had any similar cases? Any recommendations?
We had stopped using the steroid cream when he was put on oral steroids but with the last dsg change i did apply the cream since I'm sure you see the proud flesh forming.
My vet had his own surgery and will be out for 10 weeks.
I have hundreds of photos but will only upload the last dressing change but am happy to do any other you might be interested in.
Thanks for any insight since as you can imagine this has been quite upsetting. 
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Member:
lsweeney
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Posted on Saturday, Aug 20, 2016 - 6:22 pm:
Hi Mary. I'm very sorry for your long saga trying to treat your horse. I had a very similar experience with pigeon fever and I know how frustrating it can be. I ended up with the pigeon fever bacteria infecting my mares fetlock. I cold hosed it and treated it with just about everything topically I could find, but it just kept coming. UC Davis went as far to say that I was "irritating it". They gave me this stuff: https://www.woundsupplyonline.com/curasalt-dressing-p/curasalt.htm It was just a piece of dressing that was treated with curasalt. (never heard of it.) They told me to leave the bandage on for 3 days and leave it alone. They also put her on antibiotics, so the antibiotics may have been the real solution. However, I was really surprised how effective the wound dressing appeared to be. So just an FYI if infection is in play.
Generally, I have always liked to let "air" get to wounds, when most everyone is bandaging all of the time. Of course, flies come into play, and in your case, if the horse is biting at the wound, that is a problem.
My pigeon fever saga is here, and the fetlock infection is at the bottom: https://www.horseadvice.com/horse/messages/4/406350.html
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Moderator:
DrO
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Posted on Monday, Aug 22, 2016 - 5:31 pm:
Welcome Mary,
I would say you have o ne of the following or some combination:
1) A resistant infection, perhaps Pseudomonas, perhaps fungal or possibly sequential infections.
2) A unidentified foreign body.
3) A series of damaging events to the wound that set the wound back at each step including biting, the laser, perhaps a reaction to the transplant or medications, other possibilities?
The above possibilities need investigation. At this time there is no doubt the proud flesh evident in the photo needs aggressive surgical debridement and consideration of biopsy of suspicious areas on the wound margin and possibly culture.
By all means find one vet and stick with him, the wound specialist would be a good bet.
I would be interested in seeing a image of the original wound and images taken at each of the major steps described above.
DrO
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New Member:
mhorse3
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Posted on Tuesday, Aug 23, 2016 - 1:14 pm:
Hi Dr O,
Thank you for your response.
The wound specialist vet surgeon just had his own surgery and will be on leave for the next 10 weeks and he says he doesn't really know what is going on.... he has never seen anything like this. He has talked about taking it down again but i am hoping to avoid another huge vet bill. He has also mentioned the possibility that the tendon graft could be the cause. Pictures to follow..
Initial wound
pre-tendon graft
tendon graft inserted 
March 9th self mutilation
coronary band
wrap removed March 30th stinky
post surgery
healing after surgery April 27th
2 wks post laser
June 3rd skin graft done
June 23rd healing well
June 29th
July 27
I hope these pictures can give you an idea of what might be going on. There are lots more if needed.
Thanks,
mhorse3
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New Member:
mhorse3
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Posted on Tuesday, Aug 23, 2016 - 1:20 pm:
Laurie what i have run into is there seems to be very differing schools of thought on how to treat these wounds. Some say cold hose, some say keep bandaged for a moist environment, some say let dry out, ect. All has been very frustrating! Are your problems all resolved now?
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Member:
lsweeney
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Posted on Tuesday, Aug 23, 2016 - 2:27 pm:
Yes, happily, I'm not dealing with any open wounds. I remember once, a friend had a horse take a chunk out of her horse. Giant open wound. UC Davis stitched it all up, but it became infected. I remember our local vet had them rip all of the stitches out and clean it out every day. It slowly filled-in and resolved.
I had an Arab with a hairline fracture in her pastern, where the suspensory wraps around and attaches to the front of the pastern. It was not healing. She was a yearling on stall rest. She became vicious and would buck in place in her pipe corral. I finally started just taking her out and letting her eat grass, but it just wasn't really improving.
I moved to Northern California, and I told the vets that I was going to turn her out. If you look out in a pasture, the horses are rarely running around. In the new place she was in a large arena with the barn attached. She would get up every morning and run laps around the arena - round and round and round and round. After two weeks, she stopped. She became sane again. The bone healed after that.
How active is your horse on stall rest? I would be tempted to take the bandages off and walk him on pavement or grass (no dust/dirt). (Just in case he is still messing with the bandage and for sanity.) Then re-bandage for the stall.
I found this article: https://www.veterinarypracticenews.com/January-2012/Hard-to-Heal-Equine-Wounds-Pu sh-Vets/
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Member:
lsweeney
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Posted on Tuesday, Aug 23, 2016 - 2:31 pm:
https://www.thehorse.com/articles/36081/tackling-tough-to-heal-wounds
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Member:
lsweeney
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Posted on Tuesday, Aug 23, 2016 - 3:04 pm:
This was an interesting article: https://www.horsemagazine.com/thm/2015/02/trials-on-honey-treatment-for-leg-wound s-in-horses/
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New Member:
mhorse3
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Posted on Tuesday, Aug 23, 2016 - 4:17 pm:
He is actually not on stall rest anymore.After 6 months(August 4th) i begged the vet to say it was okay to to let him on pasture. I think it was harder on me than it was on my horse The first week off stall rest he ran around bucking and cantering with no problem then one day he wasn't putting weight on it and stopped running around. After about another week he started trotting, now he is okay on it.
Funny you should mention the honey treatment. I had someone last night suggest it and have been researching it today. I think i am going to try it with the next dressing change.
I would remove the bandages but as it is when i take them off to change the first thing he wants to do is turn around and bite it.
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Member:
lsweeney
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Posted on Tuesday, Aug 23, 2016 - 5:33 pm:
The weird thing about the honey, is that I have a canker sore in my mouth that is not healing very fast, and I found a suggestion on the internet for honey. I ignored it. Then I found the article above, and I think I'm going to try it!
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Member:
lsweeney
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Posted on Tuesday, Aug 23, 2016 - 6:01 pm:
https://www.woundsresearch.com/article/honey-biologic-wound-dressing
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Moderator:
DrO
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Posted on Wednesday, Aug 24, 2016 - 8:27 am:
Hello mhorse,
It is certainly possible that we are seeing sequential reinjury of the original wound and healing site though I cannot rule out any of my previous possibilities. As you have read there are dozens of ways to treat healing wounds and often the particulars depend on factors specific to individual. Most importantly is to not do anything that slows down healing. Pick a well established method and stick with it, the article associated with this discussion area outlines how I would treat a similar wound.
DrO
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New Member:
mhorse3
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Posted on Wednesday, Aug 24, 2016 - 6:47 pm:
Hi Dr O,
So I thought I had it all figured out. When I went to change my horses dressing today I noticed along the bottom edge of the wound a flap of skin had folded into the wound and was embedded in there. I called my vet who promptly said no....he said it could be part of the problem but the real problem is that the epithelial layer is not migrating across the wound bed like it should. He doesn't know why and his only suggestion would be to take wound down and put in a cast. Not an option as far as i am concerned. This horse has been through too much already.
Dr O do you know any reasons why the epithelial layer wound not be migrating like it should? 
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Member:
lsweeney
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Posted on Wednesday, Aug 24, 2016 - 7:25 pm:
https://woundcareadvisor.com/causes-prevention-treatment-epibole/
As full-thickness wounds heal, they begin to fill in from the bottom upward with granulation tissue. At the same time, wound edges contract and pull together, with movement of epithelial tissue toward the center of the wound (contraction). These epithelial cells, arising from either the wound margins or residual dermal epithelial appendages within the wound bed, begin to migrate in leapfrog or train fashion across the wound bed. Horizontal movement stops when cells meet (contact inhibition). The ideal wound edge is attached to and flush with the wound bed, moist and open with the epithelial rim thin, and pale pink to translucent.
In many chronic wounds, a problem with slow or absent epithelial edge advancement is caused by a clinical condition known as epibole. Epibole refers to rolled or curled-under closed wound edges that may be dry, callused, or hyperkeratotic. Epibole tends to be lighter in color than surrounding tissue, have a raised and rounded appearance, and may feel hard, rigid, and indurated.
Causes
Epibole results when the upper epidermal cells roll down over the lower epidermal cells and migrate down the sides of the wound instead of across. Edges that roll over ultimately cease migration secondary to contact inhibition once epithelial cells of the leading edge come in contact with other epithelial cells. In other words, the body thinks the wound is healed and epithelial migration across the top of the wound ceases. There are many possible reasons why the epidermal margin fails to migrate, including hypoxia, infection, desiccation, dressing trauma, overpacking the wound bed, unhealthy wound bed, inability to produce the basement membrane that the epithelial cells adhere to, or cellular senescence.
Prevention
Follow these tips to help prevent epibole:
• Pack dead or empty space in the wound bed. Packing promotes healing from the bottom up and avoids abscess formation at the wound depth. Fill the depth of the wound to the surface. Do not pack tightly, as this will cause pressure and impair circulation. Wound fillers, hyDrOgel impregnated gauze, alginates, or fluffed plain-woven moistened gauze can be placed loosely into the space.
• Protect periwound skin with a skin sealant, moisture barrier ointment, or barrier wafer.
• Prevent epidermal stripping by using silicone border dressings or silicone tape; consider tape-free securement strategies.
• Protect the wound from pressure.
Treatment
Treatment for epibole involves reinjuring the edges and opening up the closed tissue, which renews the healing process. Options include conservative or surgical sharp debridement, treatment with silver nitrate, and mechanical debridement by scrubbing the wound edges with monofilament fiber dressings or gauze.
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Member:
lsweeney
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Posted on Wednesday, Aug 24, 2016 - 7:55 pm:
It appears the name for this is Epibole, and I think you are exactly right. The rolled under skin is not allowing cells to fill in the wound. When I search on Eipbole, Wound, Treatment, it is mostly talking about debriding the edges of the wound: Rolled edge – Arrest the development of the new epithelial cells rolling under at the wound rim by wiping the wound edges with gauze during every change of dressing, application of silver nitrate stick, or conservative sharp debridement. The goal is to maintain an acute wound edge.
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Member:
mhorse3
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Posted on Wednesday, Aug 24, 2016 - 9:35 pm:
Wow Laurie thanks! That is just the info I was looking for. I am having a vet come out tomorrow to debride it. We'll what she has to say about it.
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Member:
lsweeney
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Posted on Wednesday, Aug 24, 2016 - 10:41 pm:
In cruising around the internet looking at pictures, and then coming back and looking at your wound, it sure seems like it fits the description! Good luck!!!!!
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Moderator:
DrO
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Posted on Thursday, Aug 25, 2016 - 9:13 am:
Hello mhorse,
Reasons for slow re-epitheliation include: excessive inflammation, recurring mechanical injury, too mature a granulation bed to feed the new cells, tissue toxic treatments, and a condition where the skin margin seem to become exhausted and will not produce more cells. Good wound care addresses each of these problems and a too mature a granulation bed is usually addressed with debridement.
DrO
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Moderator:
DrO
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Posted on Thursday, Aug 25, 2016 - 9:31 am:
Let me add to the above post that the skin folding under is not the same as what Laura is describing above. The skin has separated from the granulation bed, probably from the horses activity on the pasture, and has just folded under: it needs to be pulled out and bandages used to keep it from happening again. This may require more rest that your horse gets at pasture. The skin margin will regranulate down if not continually stretched back and forth.
DrO
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Member:
mhorse3
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Posted on Thursday, Aug 25, 2016 - 9:34 pm:
So I had a vet out this evening to assess wound. Horse would not let vet near wound. Kept throwing kicks even after being sedated X2 and twitched. When the wound is not wrapped it begins swelling quite rapidly. We managed to hose it down a little and talked about different options. We talked and the wound swelled and i noticed that the edges all smoothed out! hmm...now to keep it from folding in again when the swelling goes down. I rewrapped wound with instruction to spray with hypotonic solution when angry looking and NS when not. Thoughts?
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Member:
lsweeney
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Posted on Thursday, Aug 25, 2016 - 10:01 pm:
Where are you located?
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Moderator:
DrO
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Posted on Friday, Aug 26, 2016 - 7:42 am:
What hypotonic solution are you using and what is NS?
DrO
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Member:
mhorse3
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Posted on Friday, Aug 26, 2016 - 2:23 pm:
I'm in Indiana.
NS is 0.9% normal saline.
The vet gave me a homemade recipe for hypertonic saline but said I could try Vetrycin gel since it was basically the same thing and i happen to have some.
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Member:
mhorse3
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Posted on Friday, Aug 26, 2016 - 2:26 pm:
My mistake. Last night i said hypotonic but meant hypertonic. I was a bit frazzled
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Member:
lsweeney
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Posted on Sunday, Aug 28, 2016 - 5:31 pm:
For what it is worth, honey is making a HUGE difference on the ulcer that I have been trying to heal for at least 2 months now.
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Moderator:
DrO
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Posted on Monday, Aug 29, 2016 - 10:52 am:
Cleaning a wound with normal saline under pressure is certainly a time honored way to clean a wound. Honey has long been considered a way to treat open wounds and research suggests it can be helpful in some situations bit questions remain here is a paper that describes pros and cons of honey and gives some advice about it's use.
DrO
Medical Honey for Wound Care—Still the ‘Latest Resort’?
Arne Simon,1 Kirsten Traynor,2 Kai Santos,1 Gisela Blaser,1 Udo Bode,1 and Peter Molan3
This article has been cited by other articles in PMC.
Abstract
While the ancient Egyptians and Greeks used honey for wound care, and a broad spectrum of wounds are treated all over the world with natural unprocessed honeys from different sources, Medihoney™ has been one of the first medically certified honeys licensed as a medical product for professional wound care in Europe and Australia. Our experience with medical honey in wound care refers only to this product. In this review, we put our clinical experience into a broader perspective to comment on the use of medical honey in wound care. More prospective randomized studies on a wider range of types of wounds are needed to confirm the safety and efficacy of medical honey in wound care. Nonetheless, the current evidence confirming the antibacterial properties and additional beneficial effects of medical honey on wound healing should encourage other wound care professionals to use CE-certified honey dressings with standardized antibacterial activity, such as Medihoney™ products, as an alternative treatment approach in wounds of different natures.
Keywords: Medical honey, wound care, MRSA
Introduction
In our paediatric oncology department at the Children's Hospital Medical Centre, University of Bonn, Germany most patients suffer from a profoundly suppressed immune system, due to their underlying disease (i.e. leukemia) (1) and the chemotherapy they undergo. This frequently results in wound healing problems (2,3), leaving the patient susceptible to wound infections. Unfortunately these infections spread easily in immunocompromized patients and can cause secondary potentially life-threatening bloodstream infections (4).
Five years ago a 12-year old patient was submitted to our unit. Doctors at another hospital had removed an abdominal lymphoma, leaving an open drainage site on his abdomen. On admission, his wound was infected with methicillin-resistant Staphylococcus aureus (MRSA). In order to avoid nosocomial spread, the patient was immediately isolated, a difficult situation for the child to comprehend with significant additional costs from the perspective of the hospital. Although the patient was scheduled to receive chemotherapy, treatment could not commence until the infection cleared. The wound was treated with a local antiseptic (octenidin) for 12 days. Since no improvement occurred, we decided to use an Australian medical honey (Medihoney™), which contains leptospermum honey, a type with excellent in vitro activity against MRSA (5–7). The wound was free of bacteria two days later, and the chemotherapy against the underlying illness could be started.
While the ancient Egyptians and Greeks used honey for wound care, a broad spectrum of wounds are treated all over the world with natural unprocessed honeys from different sources (8–13), Medihoney™ has been one of the first medically certified honeys licensed as medical product for professional wound care in Europe and Australia (14,15). Our experience with medical honey in wound care refers only to this product. We were asked by one of the editors of eCAM to put our clinical experience (2,16) into a broader perspective and to comment on the use of medical honey in wound care (Table 1).
What Makes Medical Honey Effective?
Honey works differently from antibiotics, which attack the bacteria's cell wall or inhibit intracellular metabolic pathways. Honey is hygroscopic, meaning it draws moisture out of the environment and thus dehydrates bacteria. Its sugar content is also high enough to hinder the growth of microbes, but the sugar content alone is not the sole reason for honey's antibacterial properties.
When honey is diluted with water, reducing its high sugar content, it still inhibits the growth of many different bacterial species that cause wound infections (14,15,17–20).
Leptospermum spp. are known by a number of common names in Australia and New Zealand including Tea Tree, Manuka, Goo Bush and Jelly Bush. A least 79 species of Leptospermum have been described in Australia and New Zealand (21). The medical honey, our clinical experience refers to (Medihoney™), consists of standard mixture of different Leptospermum spp. honeys (Fig. 1), and exhibits a standard antibacterial activity as confirmed by appropriate in vitro testing methods (22).
Unlike glucose oxidase, the antibacterial properties from Leptospermum spp. honeys are light- and heat-stable. Neither type of activity is influenced by the final sterilizing procedure of gamma-irradiation (23). Over 100 substances are candidates for the particular antibacterial property of these honeys, but the active ingredient has not yet been identified. Even if the hyDrOgen peroxide activity is blocked and the osmotic effect of honey is circumvented by dilution, selected honeys from Leptospermum spp. still display significant antibacterial effects. Natural honey of other sources can vary as much as 100-fold in the potency of their antibacterial activity (which is due to hyDrOgen peroxide) (5–7,24–27).
In addition to its antibacterial properties, medical honey hastens the healing of wounds through its anti-inflammatory effects. The amount of wound exudate is related to the activity of the local inflammatory process, in particular in wounds, which are colonized or infected with bacteria. Thus, the anti-inflammatory action of honey reduces oedema and the amount of exudate by down regulating the inflammatory process. It also reduces pain, as the pain in wounds results from the nerve endings being sensitized by prostaglandins produced in the process of inflammation, as well from the pressure on tissues resulting from oedema.
Due to its high sugar content, honey also prevents pain on dressing changes as it keeps the wound surface moist by mobilizing the oedema from the surrounding tissues.
The anti-inflammatory action of honey has been extensively observed clinically (19,28,29) and in animal models (15). Animals do not demonstrate any placebo effects, as they are incapable of having attitudes influence their healing process, such as believing that natural products would be more effective, or from hearing via the news media of the effectiveness of honey in wound treatment (30). Thus, these observational and histological studies can be cited as convincing evidence for the positive results with honey not being due to a placebo effect. Similarly, this can be concluded also for the observations in wounds in animal models of honey stimulating the rate of angiogenesis, granulation and epithelialization (31,32), which would explain the findings in clinical trials that honey speeds up the healing process (15).
Although the mechanism(s) by which honey speeds up the healing process have not been determined, there are some findings, which provide possible explanations. One way in which honey may work is through its stimulation of an inflammatory response in leukocytes (28,29,33), as inflammation is what triggers the cascade of cellular events that give rise to the production of growth factors which control angiogenesis and proliferation of fibroblasts and epithelial cells. Very recently, Tonks et al. discovered a 5.8?kDA component of manuka honey which stimulates the production of TNF-a in macrophages via Toll-like receptor 4 (34).
Another mechanism may be related to the pH level of honey being low (3.4–5.5; mean 4.4) (35,36). Bacterial colonization or infection and recalcitrant wound healing situations are often accompanied by pH values >7.3 in wound exudates (37,38). It has been demonstrated that acidification of wounds speeds healing (39), this being attributed to the low pH increasing the amount of oxygen off-loaded from hemoglobin in the capillaries. More recently it has also been attributed to suppression of protease activity in wounds by getting away from the neutral pH that is the optimum for their activity (37). Excessive protease activity in a wound can slow or prevent healing by destroying growth factors (which are proteins) and destroying the protein fibres and fibronectin in the wound matrix, attachment to which activates fibroblasts and is necessary for the migration of these and of epithelial cells (https://www.worldwidewounds.com/2005/august/Schultz/Extrace-Matric-Acute-Chronic- Wounds.html). This protease activity results from excessive inflammation. The anti-inflammatory activity of honey would thus remove this impediment to healing, as would the antibacterial activity working through removing infecting bacteria stimulating the inflammatory response.
The remarkable debriding action of honey that has been noted by many would also assist in this by removing slough which is a rich source of bacteria to stimulate an inflammatory response (19).
Last but not least, medical honey successfully manages the problem of malodour from chronic colonized wounds, which results in severe discomfort and social isolation in these patients. We relate the experience of one female patient with relapsed breast cancer after chemotherapy and irradiation. Her husband informed us, that other members of the family would not enter her room, because her wound smelled like a ‘dead rabbit’. This malodour problem was successfully eliminated with the application of medical honey in 2 weeks.
Why is the Final Product Irradiated?
Clostridium botulinum spores pervade our environment, existing in the soil, air, dust and raw agricultural products. Due to the possibility of Clostridial contamination and many reports of infant botulism in the literature since the first description of this synDrOme in 1976, it has been recommended by paediatricians, not to feed infants with honey and to place warning labels on packaging, as done in the United Kingdom and Norway (36).
In deep wound cavities the possibility exists of an anaerobic environment, where the spores could proliferate and produce botulinum toxin. Negative effects such as paralysis and cardiac arrhythmia have been described related to systemic effects of the toxin. To eliminate botulism spores with heat, honey must be heated to 120°C (248°F) for 10?min, which results in adverse changes to some of honeys’ beneficial properties. Since spores have occasionally been found in honey, each batch of Medihoney™ is gamma irradiated to inactivate spores such as those from Clostridium spp. This does not have a detrimental impact on the antibacterial activity of honey. On the other hand, irradiating honey is only a safety measure on the side of caution since we (40) could not detect a single case report in the literature of C. botulinum wound infection related to the use of non-irradiated honey in wound care (41).
Medihoney is not an Antiseptic
An ideal wound antiseptic would meet the following criteria (42):
Fast onset of bactericidal action and a remnant, broad spectrum effect against bacteria and fungi, even under the unfavorable conditions of exudating, colonized or infected wounds.
Enhancement and acceleration of the physiologic process of wound healing (debridement, granulation), even if applied for prolonged periods.
No adverse local or systemic effects (allergy, toxicity related to absorption).
Moderate cost even if applied two times daily.
Medihoney meets all of the above criteria except ‘a fast onset of activity’, as it does not seem to produce the desired reduction of bacteria (more than five log steps) and fungi in 1–10?min to be qualified as an antiseptic.
Go to:
What About Conventional Wound Care Products in Paediatric Oncology?
Some of the parents in our unit have at first been sceptical about the benefits of honey in wound care. However, the scientific evidence for using conventional wound care products in paediatric oncology patients is non-existent, since no prospective randomized studies have been performed in this particular population and no research has been done on the long-term effects of modern conventional treatments such as silver dressings.
There has been a report of a Silver-coated dressing which caused raised liver enzymes and an argyria-like synDrOme in an adolescent burn patient (43). Another common treatment is povidone iodine, which has the advantage of antiseptic properties and is well suited for skin disinfection prior to invasive procedures. However, the antiseptic activity of iodine products is hampered by interactions with the protein content of the wound exudate and severe adverse effects of systemic absorption of iodine on thyroid function must be considered in infants and toddlers as well as in adult patients with latent hyperthyreosis.
In principle, the same problem exists with alcohol-containing antiseptics, since they are almost completely absorbed and need to be metabolized by the children, who are treated concomitantly with many other drugs. In contrast, medical honey does not display the problem of systemic absorption and thus can even be utilized in patients with diabetes mellitus without adverse effects on blood glucose levels.
Medical Honey in Severely Immunocompromized Patients?
One of our patients with acute myeloic leukemia in relapse had a wound infection with methicillin-resistant coagulase-negative staphylococci after thoracic surgery for invasive Aspergillus infection of the lung, but was allocated to allogenic bone marrow transplantation. Using medical honey, the infection was eliminated.
The patient continued to receive medical honey applications during and after the transplantation (Fig. 2), leading to a successful healing without further local or systemic complications.
Medical Honey for Recalcitrant Wounds
Many of the 150 wound care patients we have treated with medical honey had previously received specialist attention for recalcitrant wounds (2,3,16,44). When treatment with honey was commenced, their wound status changed to healing from non-healing (2,3,16,44). Similar findings have been reported by others (19,45).
Medihoney™ for the protection Of Catheter Entry Sites
The clinical usefulness of hemodialysis catheters is limited by increased infectious morbidity and mortality. Topical antiseptic agents, such as mupirocin, are effective at reducing this risk but have been reported to select for antibiotic-resistant strains. Johnson et al. (46) performed a randomized, controlled trial comparing the effect of thrice-weekly exit-site application of Medihoney™ versus mupirocin on infection rates in patients who were receiving hemodialysis via tunnelled, cuffed central venous catheters. A total of 101 patients were enrolled. The incidences of catheter-associated bacteremia in honey-treated (n?=?51) and mupirocin-treated (n?=?50) patients were comparable (0.97 versus 0.85 episodes per 1000 catheter-days, respectively; NS). No exit-site infections occurred. During the study period, 2% of staphylococcal isolates within the hospital were mupirocin resistant. Thrice-weekly application of standardized antibacterial honey to hemodialysis catheter exit sites was safe, cheap, and effective and resulted in a comparable rate of catheter-associated infection to that obtained with mupirocin (although the study was not adequately powered to assess therapeutic equivalence).
The effectiveness of honey against antibiotic-resistant microorganisms and its low likelihood of selecting for further resistant strains suggest that this agent may represent a satisfactory alternative means of chemoprophylaxis in patients with central venous catheters. In our paediatric oncology unit, all entry sites of tunnelled central venous catheters, which show any sign of inflammation or dehiscence, are covered with medical honey.
Honey Treatment for Prevention of Oral Mucositis and for Gingivitis
Many cancer patients suffer from mucositis, a side effect of chemotherapy that attacks the entire gastrointestinal tract from the mouth to the anus. The cancer treatment breaks down the epithelial cells lining the tract, leaving the patient prone to ulcerations and infections. These important and beneficial cells replicate and divide rapidly, which is why in a typical healthy individual wounds in the mouth heal quickly. Chemotherapy does not distinguish between healthy and malignant cells, attacking all that reproduce rapidly, including these epithelial cells.
Thus 20–40% of all cancer patients receiving intensive chemotherapy suffer from mucositis, the number climbs to 80% when chemotherapy and radiation are combined, and staggers even higher in patients receiving treatment for cancer in the head and neck area. Open sores in cancer patients suffering from mucositis leave them susceptible to infection. In a study conducted in 2003, Biswal et al. (47) investigated the use of honey in 40 adult patients with head and neck cancer. Patients consumed 20?ml (one and one-third teaspoon) of pure honey 15?min before, 15?min after and 6?h post-treatment. There was significant reduction in the symptomatic grade three-fourth mucositis (which describes the necessity for morphine infusion and parenteral nutrition) among honey-treated patients compared with controls; i.e. 20% versus 75% (P < 0.001).
The compliance of the honey-treated group of patients was better than controls. A total of 55%patients treated with topical honey showed no change or a positive gain in body weight compared with only 25% in the control arm (P?=?0.05). According to a recent review, honey has potential for the treatment of periodontal disease, mouth ulcers and other problems of oral health (48), and a trial has demonstrated a statistically significant difference between chewing gelled honey and chewing chewing-gum in decreasing the number of bleeding sites on gums with gingivitis (49).
Use of Honey for Wound Care in Neonates
Due to the safeness of Medihoney™, we used this product for wound care in premature neonates. One infant patient had a recalcitrant wound after surgical intervention for meningomyelocele. The wound stagnated, and during intensive care treatment, it became colonized with multiresistant Klebsiella oxitoca. Before treatment with Medihoney™ was initiated, the child had received numerous intravenous antibiotics and many other conventional wound care treatments to clear the wound, spending the first 3 months of its life in the hospital. Medihoney™ dressings cleared the wound of the pathogen and allowed the patient to be discharged after 3 weeks. The wound healed completely without further surgical intervention. Viardi et al. (40) published an impressive case series including nine neonates with polymicrobial wound infection after surgery for congenital heart disease. All infants were considered as treatment failures, since chlorhexidine 0.05% plus fusidic acid ointment plus systemic antibiotics did not result in any improvement of the sternal wound infection. All infants showed marked clinical improvement after 5 days of treatment with topical application of 5–10?ml of fresh unprocessed (non-pasteurized, non-irradiated) honey twice daily. The wounds were closed, clean and sterile in all infants after 21 days of honey application. There were no adverse reactions to the treatment. In a recent review for Neonatal Network, Susan Bell reviewed the current literature dealing with the medical use of medical honey in neonatal wound care. Nurses in her unit are using medical honey for this purpose since 2005. She came to the conclusion that the scientific evidence regarding the use of honey for wound treatment in neonates and infants is interesting, but still not strong. The sample sizes in the available clinical studies were small; there were no comparison groups and no randomization. She stated that double-blinded randomized controlled clinical trials with sufficient power are needed to determine the efficacy of honey in both initial wound management and secondary treatment of infected and poorly healing wounds. It has to be questioned, how double or even single (on the side of the patent) blinding can be established in studies, which investigate medical honey for wound care and compare it with other conventional modes of treatment.
Honey Treatment Against Viral Disease
Al-Waili et al. published a cross over trial (9) in which 16 adult patients with a history of recurrent attacks of herpetic lesions, 8 labial and 8 genital, were treated by topical application of honey for one attack and acyclovir cream for another attack. For labial herpes, the mean duration of attacks and pain, occurrence of crusting and mean healing time with honey treatment were 35, 39, 28 and 43% shorter, respectively, than with acyclovir treatment. For genital herpes, the mean duration of attacks and pain, occurrence of crusting and mean healing time with honey treatment were 53, 50, 49 and 59% shorter, respectively, than with acyclovir. Two cases of labial herpes and one case of genital herpes remitted completely with the use of honey. No side effects were observed with repeated applications of honey, whereas three patients developed local itching with acyclovir. The authors came to the conclusion that topical honey application is safe and effective in the management of the signs and symptoms of recurrent lesions from labial and genital herpes (9). According to this experience, we treat children and adults with recurrent herpetic lesions on the lips with medical honey, as soon as a new lesion is developing. In addition, we use topical medical honey in addition to systemic acyclovir in immunocompromized patients with zoster to prevent secondary bacterial skin infection and to accelerate healing of the herpetic lesions.
Medical Honey in Chronic Ocular Surface Diseases
Albietz et al. (50) recently published the results of a study that assessed the effect of Medihoney™ antibacterial honey on the ocular flora in patients with dry eye caused by tear deficiency and/or Meibomian gland disease. In this prospective, open-label pilot study, bacteria isolated from the eyelid margin and conjunctiva were identified and quantified before and at 1 and 3 months after initiation of treatment with topical application of antibacterial honey thrice daily. The total colony-forming units (CFUs) isolated from each of the dry eye subgroups before antibacterial honey use was significantly greater than the total CFU isolated from the non-dry eye group.
Use of Medihoney™ Antibacterial honey significantly reduced total CFUs for the eyelids and the conjunctiva of dry eye subjects from baseline at month 1 and 3. At month 3, the total CFUs for all dry eye subgroups were not significantly different from those of the non-dry eye group. A review of the medical uses of honey (8) has cited several other reports of honey, an ancient treatment for sore eyes, being found to be successful in modern ophthalmology.
Comparing Different Types of Honey
A comparison of different types of honey, which is beyond the scope of this article, may be an important issue in future trials (24). In particular the results obtained by Prof. Descotte from France, presented during several international Apitherapy meetings, point into this direction; unfortunately they have not been published in a medline listed journal. Irish et al. (51) found Jarrah honey (derived from Eucalyptus marginata), which contains higher amounts of glucose oxidase, to be significantly more effective against Candida spp. in vitro; the activity of the other honeys including Medihoney™ against Candida spp. with minimal inhibitory concentrations above 40% (w/v) were not distinguishable from the activity of an artificial honey.
Minimal Requirements for Clinical Use
From a professional medical perspective honey used in wound care should have a proven antibacterial activity against the most important pathogens in wound infection (S. aureus, Pseudomonas aeruginosa) (16,52) measured with an appropriate microbiological in vitro method (5,25,27,51,52). In addition, it should be irradiated (23) in particular if it is used in deep or partially necrotic wounds (53) which possess a potential of anaerobic wound conditions. Surely, we do not criticize the emergency care use of raw honey directly derived from local bee keepers in countries with extremely limited medical resources (54) in which physicians or other health care workers do not have access to conventional wound care products (13,55–57).
Who Should Supervise the Use of Medical Honey in Clinical Practice?
For safety reasons, wound care with medical honey should always be supervised by a physician or an experienced wound care nurse in patients with chronic complicated wounds or with significant comorbidities. The ‘honey approach’ to wound care must be part of a comprehensive wound care concept. Any comorbidity which contributes to the problems in wound healing should be diagnosed and treated thoroughly with state of the art interventions (e.g. bypass surgery in patients with reduced arterial perfusion, compressive bandages in patients with chronic venous ulcers, sufficient control of blood glucose levels in patients with diabetic food synDrOme) (58).
Honey Must be Kept in Contact to the Wound
Medical honey dressings should keep the honey in contact with the wound for at least 12?h, but preferably for 24?h. Some patients apply the wound dressing overnight, so as not to restrict their mobility during the day. If the dressing is inappropriate, the honey may be washed out of the wound by exudate. The clinical benefits of medical honey including antibacterial protection, wound cleaning and pH modulation may as a result be reduced. From our experience (2) and the experience of others (59), the best way to keep the honey in the wound is to soak medical honey into a calcium-alginate or hyDrOfiber dressing, which forms a gel with the honey as it absorbs the exudate. The various registered medical honey products available, some in the form of prepared honey-impregnated dressings, have been described (14,45).
When to Use Systemic Antibiotics Concomitantly
In case of an infected wound or in case of colonization with a multiresistant bacterial isolate, a hospital grade, licensed antiseptic (e.g. octenidine) is applied to the wound in addition to Medihoney™ on the first 2 days of treatment. In patients with neutropenia (neutrophil count <0.5?×?109?l-1 or leukocyte counts <1?×?109?l-1 and no differential count available) systemic antibiotics have to be administered concomitantly after a local wound swab has been taken if fever or local sign reveals soft tissue infection. With hospitals facing increasing problems of bacterial resistance, it is important to note that the use of medical honey has never been observed to foster bacterial resistance (20).
Frequency of Dressing Changes
The frequency of dressing changes depends on the amount of exudate. In early stages, fresh surgical wounds infected with pathogenic bacteria may necessitate a dressing change twice a day. In stable wound care situations, the Medihoney™ dressing has been left in place for up to 7 days (58,60). Prospective studies confirming the safety of such an extended dressing change interval are not yet available.
Compliance Issues
Dunford et al. (61) undertook a four-center feasibility study to determine whether Medihoney™ is an acceptable treatment for patients with leg ulcers in terms of pain relief, odour control and overall patient satisfaction. A total of 40 patients whose leg ulcers had not responded to 12 weeks of compression therapy were recruited. Medihoney dressings were applied on their ulcers for the 12-week study period. All other aspects of their care, including the use of compression bandaging, remained unchanged. Overall, ulcer pain and size decreased significantly and odorous wounds were deodorized promptly.
These results revealed a high patient acceptance for and concordance with this treatment. The same first author reported the care of an adolescent with multiple wounds, infected with resistant bacterial pathogens after meningococcal sepsis and limb amputation (62). Before the use of medical honey, each dressing change had to be performed under general anaesthesia to alleviate pain and anxiety. Shortly after the introduction of medical honey dressings, the wounds improved and dressing changes could be performed without any analgesic medication. We have had similar experiences with children in our clinic. If the medical honey dressing is completely moistened with sterile Ringer solution, it can easily and painlessly be removed without any negative attachment to the wound. In our unit and our wound care ambulance, parents or relatives are educated in the aseptic procedure of the dressing change and thus, they are enabled to perform it at home.
Adverse Effects
There are two important adverse effects related to the use of medical honey. We have observed in about 5% of our patients stinging pain after administration. This problem may be circumvented by the conditioning of the wound surface with a sterile anaesthetic cream. Unfortunately, local anaesthetics cause vasoconstriction. Thus, the application of an anaesthetic to the wound surface may result in an objectionable reduction of local perfusion. In some patients who experienced pain after administration, treatment with medical honey had to be stopped (16) or postponed to later phases of wound healing after the acute inflammatory process has been controlled by other approaches. Two of 150 patients from our patient population showed reproducible local atopic reactions to Medihoney™. Both children had an underlying atopic disposition. We are not aware of any severe systemic atopic reaction related to the use of medical honey from our experience and from the published literature.
Cost Issues
Ingle et al. (63) from South Africa performed a randomized controlled trail to investigated the use of natural honey (monofloral aloe honey) in shallow wounds, donor sites for skin grafting and partial thickness burns in 44 goldmine workers. They compared this group with another group of 43 workers whose wounds were treated with IntraSite™ Gel (Smith and Nephew Ltd). They did not find significant differences in healing time, adverse events (itching, pain) and satisfaction with treatment but the average cost of the use of honey was 4% that of IntraSite™ treatment. More prospective studies investigating the overall cost of treatment with medical honey compared with conventional wound care approaches are awaited (64) in particular in chronic, recalcitrant wounds. In clinical practice, the use of calcium alginate or hyDrOfiber gauzes and semipermeable dressings to keep the honey in the wound has to be added to the acquisition cost of the medical honey. To contain the demands on personnel resources, it would be of outstanding interest to develop ready to use medical honey dressings, which have to be changed only every 2–3 days even in acute wound care situations.
WoundViewer© Database
We recently developed a database for the standardized prospective collection of datasets considering the clinical use of medical honey products in wound care to foster the collection of clinical evidence to help design prospective comparative studies in the near future.
Conclusion
More prospective randomized studies on a wider range of types of wounds are needed to confirm the safety and efficacy of medical honey in wound care (65). Nonetheless, the current evidence (15) confirming the antibacterial properties and additional beneficial effects of medical honey on wound healing should encourage other wound care professionals to use CE-certified honey dressings with standardized antibacterial activity, such as Medihoney™ products, as an alternative treatment approach in wounds of different natures.
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Member:
lsweeney
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Posted on Monday, Aug 29, 2016 - 1:07 pm:
All I know is that it is a miracle drug to me right now. I have been in excruciating pain 24/7, eating and talking was unbelievably painful! Between my post on 8/23 and today, I'm just about pain free now, and it is clearly resolving.
I did read that you need to make sure that it should be medical grade.
I just used store-bought honey. Feeling GREAT today.
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Member:
mhorse3
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Posted on Tuesday, Aug 30, 2016 - 6:46 pm:
Well I rebandaged horses leg tonight. More inflamed with purulent looking drainage. Very frustrated. I had used Veterycin gel with last bandage change and it looks worse today! In total frustration i gobbed some honey on and rewrapped. I've had about 10 people tell me honey so we shall see. The Manuka honey i had bought at the drug store was not wide enough for wound so i went with raw honey. I had read a study by a vet that concluded it didn't need to be the Manuka honey in fact some other honeys worked better.
The vet that was here last Friday had me finish up the sulfa tabs and didn't think i needed more so he has been off antibiotics for a couple days. Should i start them back up? i have a call in to her but wondered your opinion.
Thanks, Mary
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Member:
lsweeney
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Posted on Tuesday, Aug 30, 2016 - 8:42 pm:
The reason I asked about your location was that I was wondering if there were any veterinary schools close to you. I have had good luck with UC Davis in California. They are typically cheaper than the local vets, and they have a lot of resources available.
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Member:
mhorse3
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Posted on Tuesday, Aug 30, 2016 - 10:22 pm:
I have talked to vets at both Purdue and Michigan state about my horses injury. At Purdue where the vet surgeon was trained they put the horses in casts. The vet at Michigan state was a surgeon who has been practicing for 50 years. He said he would have cut the tendon completely and put him out to pasture for 6 months!
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Member:
lsweeney
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Posted on Tuesday, Aug 30, 2016 - 11:39 pm:
What about UC Davis in California?
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Moderator:
DrO
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Posted on Wednesday, Aug 31, 2016 - 10:51 am:
Hello mhorse,
Casts can work but they can be difficult to care for with complications (cast sores) common. I would not put them over a purulent or swollen wound. I am not sure why he would but the tendon and would be interested in his reply. Perhaps he believes the two moving ends continue to prevent the wound from granulating in properly?
The question about whether antibiotics should be continued must be addressed by a veterinarian who can examine the wound. You keep wanting to attribute how the wound is doing to WHAT product you are using but these products are not as important as HOW you treat the wound. of problems you are seeing when I use them. I still don't see evidence you are following the recommendations in the article, again I recommend you study them and discuss with your veterinarian how they might be applied to your horse.
DrO
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Member:
mhorse3
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Posted on Wednesday, Aug 31, 2016 - 3:41 pm:
Hi Dr O,
Sorry if i was not clear about the cast. His suggestion was to surgically take down the wound (start all over) and then cast. He says he casts most of his wound because motion is what will keep a wound from healing properly.
I have followed each veterinarians recommendation on how to treat the wound. When the wound has not responded as it is suppose to and the vet doesn't know why i have sought other opinions and other modalities but i have basically been cleaning wound with water or saline and wrapping up. When proud flesh appeared and it became angry i applied a steroid cream as directed.
The big question is why it appears to be healing nicely and then suddenly becomes angry again without any difference in how it is being treated.
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