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HorseAdvice.com » Diseases of Horses » Lameness » Diseases of the Hoof » Navicular Disease / Chronic Heel Pain SynDrOme »
  Discussion on Osphos for navicular synDrOme
Author Message
Member:
cowboysm

Posted on Wednesday, Aug 23, 2017 - 7:54 am:

Have a 9 yr old QH that received OSPHOS injection for navicular disease. I was wondering if anyone has had experience with this treatment.
Moderator:
DrO

Posted on Thursday, Aug 24, 2017 - 10:10 am:

Hello cowboysmom,
Has the particular cause for the navicular disease been identified?
DrO
PS
After this rather promising work there has been a dirth of research into bisphosphonates in general and Osphos in particular:

Equine Vet J. 2003 Jun;35(4):407-13.
TiluDrOnate as a new therapeutic agent in the treatment of navicular disease: a double-blind placebo-controlled clinical trial.
Denoix JM1, Thibaud D, Riccio B.

Abstract
REASONS FOR PERFORMING STUDY:
Bisphosphonates, such as tiluDrOnate, are used to normalise bone metabolism via inhibition of bone resorption. Areas of increased bone resorption and formation are typical lesions in a diseased navicular bone.
OBJECTIVES:
To determine if bone remodelling changes occurring in navicular disease may be corrected with therapies regulating bone metabolism.
METHODS:
We designed a double-blind, placebo-controlled clinical trial to compare 2 doses of tiluDrOnate, 0.5 mg/kg and 1 mg/kg bwt administered via daily i.v. injections over 10 days for the treatment of navicular disease. Seventy-three horses, split into 2 subpopulations of recent and chronic cases, were enrolled to be followed-up over 6 months. Of these, 33 recent and 17 chronic cases meeting the selection criteria were maintained in the final efficacy analyses. Clinical examinations were videorecorded and reviewed blindly by an independent expert.
RESULTS:
Horses treated with the higher dose showed optimal improvement of lameness and return to normal level of activity 2-6 months post treatment. The more recent the onset of clinical signs at the time of treatment, the greater the efficacy. The treatment did not modify the response to extension and flexion tests. The lower dose failed to significantly improve the condition.
CONCLUSIONS:
TiluDrOnate efficacy is demonstrated in the treatment of navicular disease at the dose of 1 mg/kg bwt.
POTENTIAL RELEVANCE:
Our results support the clinical relevance of bone remodelling changes in the outcome of navicular disease.
Member:
cowboysm

Posted on Thursday, Aug 24, 2017 - 9:03 pm:

No. A cause was not discussed. Radiographic changes in the navicular bone were degenerative changes/opacities. Worse on left consistent with left fore lameness. Was mentioned that his smaller feet and big muscled conformation was common with navicular disease.
Member:
cowboysm

Posted on Friday, Aug 25, 2017 - 9:44 am:

Your question got me thinking. He also has soft soles and I'm wondering if the concussion on trail rides,hills,rocks has added to the trauma to the area. He also has weak hoof walls and is on double dose hoof suppliments and has keratex applied to walls regularly.
Moderator:
DrO

Posted on Saturday, Aug 26, 2017 - 3:05 pm:

Check out, HorseAdvice.com » Diseases of Horses » Lameness » Diseases of the Hoof » Wall Cracks and Thin Sensitive Soles.
DrO
New Member:
rowan555

Posted on Saturday, Sep 9, 2017 - 8:49 pm:

I live in Florida unfortunately I am in the path of Irma and waiting for the hit. I recently purchased a grey dapple 8 y/o TB OTTB pony/horse from Ocala who has laminitis and has a slight rotation at P3 in the right front. I have had the vet take x-rays and recommended that I give him 2 grams of bute for 5 days and 1 gram for 5 days.The vet also said that he should be confined to the stall and feed would be low carb Nutrena low carb grain and Eqisafe wellness hay. His new feed has been helping. However, I transferred him to a different stall and he is limping again and is in pain. I don't know what else to do. The vet says it takes time. It's been 6 weeks. However to see him struggling to walk breaks my heart. 3 weeks ago the farrier put special shoes in the front. Albeit, I have put dura sole to toughen his back feet he still seems to have pain in the back too. The new stable does not leave him in his stall. They put him in the turnout with grass and they feel that is better for him. Now we have to deal with the hurricane Irma and I am afraid to loose my horse. Please advise on how I can protect my horse. I have done everything I can. I'm constantly calling the vet. I don't want to give him up and I will do everything I can to help him. Could he have navicular issues. Please advise. Thank you Myrna
Moderator:
DrO

Posted on Monday, Sep 11, 2017 - 8:21 am:

Welcome Myma,
From your description there are many possibilities. The problem you have is you need a diagnosis before you can give proper treatment and prognosis. Past rotation is not proof that the horse currently suffers from laminitis. For more on this see HorseAdvice.com » Diseases of Horses » Lameness » Localizing Lameness in the Horse. If you feel that there may be unaddressed issues after working with your veterinarian for weeks you need a second opinion. Then again if the vet has given good advice on treatment and the barn will not follow the proscribed treatment you need a new barn.
DrO
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