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  Discussion on Sarcoid and auto-immune therapy
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DrO

Posted on Monday, Aug 22, 2005 - 9:57 am:

Though early work with Sarcoid vaccines created from the horses tumor were disappointing recent successes are causing renewed interest in this technique. Here a researcher from Finland had remarkable success. Interestingly the healing did not seem to involve an attack of the tumor by the immune system but seemed to stimulate growth of normal skin, crowding out the tumor cells. The earlier paper suggests that vaccine production may be a bit more complicated, by polymerization, than earlier autologous vaccines so it remains to be seen if a company will start producing this.

In Vivo. 2005 Jul-Aug;19(4):761-7.
Macroscopical and histopathological changes in regressing primary and recurrent equine sarcoids during active specific bio-immunotherapy.
Hallamaa RE, Saario E, Tallberg T
Veterinary Clinic, Pisteenkaari 4, 03100 Nummela, Finland.

Healing sarcoids were followed in 18 horses which had taken part in previous clinical studies on a total of 29 horses suffering from either primary or recurrent sarcoids, treated with bio-immunotherapy. In the present study, attention was paid to changes observed in these fibroblastic skin tumours during their regression. The tumours were surgically debulked leaving the base in the skin. The horses were immunized according to bio-immunotherapy at 2- to 4-week intervals with an autogenous vaccine made from the excised part of the tumour until the base had visibly regressed. Healing was followed by inspections and serial biopsies from the base, studied under light microscope. Visibly normal epithelisation developed first at the margin of the base, progressing gradually to the centre. The mean rate of epithelisation was approximately equal to normal horse skin. Most of the histopathological features typical of equine sarcoid diminished significantly in the follow-up biopsies, when the first signs of visibly normal epithelisation were observed. The changes were more evident among the primary than the recurrent tumours. No leucocyte infiltration, lysis or apoptosis were found during the regression. Bio-immunotherapy seems to simulate a spontaneous healing process.



Anticancer Res. 1999 Jul-Aug;19(4C):3367-74.
Equine sarcoid tumour treated by autogenous tumour vaccine.
Kinnunen RE, Tallberg T, Stenback H, Sarna S.

Veterinary Clinic, Nummela, Finland.

Twenty-one horses with sarcoid tumours were treated by bio-immunotherapy using autogenous vaccines during 1991-1997. At operation the base of the tumour was left in the skin and autovaccines were made from extirpated tumour tissue by polymerization. The horses thus formed their own internal control group. One of 12 horses having a primary tumour, and four of 9 horses suffering recurrent tumours, prior to bio-immunotherapy, developed single recurrences. Four of these five horses suffering recurrence were treated anew, leading to remission. Disease-free intervals were longer for primary (P = 0.0005) and recurrent sarcoids (P = 0.0156) than for conventional surgery alone. Mitochondrial events seem to effect the healing.
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