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Discussion on Oral Reserpine v/s Injectable
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New Member:
Shantal
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Posted on Friday, Dec 31, 2004 - 4:32 pm:
I am hoping that the Dr. can give me some advice about proper oral dosing of reserpine. I have used injectable reserpine a few times in the past when I was re-training TB's off the track. I only used it short term on the most difficult horses. I had a great deal of success with this medication when used on horses that have been abused or mentally over-stressed. Generally, after two to three months of patient, consistant work and reserpine, the reserpine was no longer needed. I recently purchased a very nice Belgian draft gelding who has unfortunately been mis-treated by his former (Amish) owners. He is very nervous and skittish. Months of patience and training have not improved him. I feel he's an excellent candidate for short term reserpine "therapy". I asked my vet to order the injectable but she had difficulty locating it. She was able to find the tablets for me. They are .25mg each. The injectable I used previously was .5mg per ml and I was giving 1 dose of 3ml about evey 2 weeks. I am wondering about the oral dose. Do you have to give more? I have also heard of people giving an initial dose of 1mg to 2mg and then giving another dose the next day. Is that really necessary? I am also wondering if I should give a lower dose to a draft. I have found that even though drafts are heavier than TB's they tend to be much more sensitive to tranqs. My vet does not have any experience with reserpine so I am hoping to get good advice here. Thank you!
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Moderator:
DrO
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Posted on Saturday, Jan 1, 2005 - 10:15 am:
I have only limited experience with reserpine and none in drafts but think I can help you with your other questions. Since reserpine is well absorbed from the gi tract, similar doses to IM injection should be used.
The reason for the slowly titrated dose is the very low therapeutic / toxic index (see article). By slowly building the dose you might prevent an unusually sensitive horse from having a serious reaction of over sedation.
DrO
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