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Discussion on Half Life of Acepromazine
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Member:
Trigster
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Posted on Friday, Dec 31, 2004 - 9:44 pm:
What is the half life of ace given orally? I have a 22 yo appaloosa who has serious freakouts over fireworks. He weighs about 1000 lbs and I dose him with 40 mg. After about 1 hour, he's feeling good. Alert to his surroundings, but not running into fences and gates. However, at about hour 2.5 to 3, he starts getting excitable again. Is it safe to give him another dose? If so, how much? I understand that ace has a wide safety margin, but I cannot find anything on the web as to how far apart dosing should be. However, I am afraid that not keeping him sedated will put him at great risk of physical injury.
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Member:
Eoeo
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Posted on Friday, Dec 31, 2004 - 11:43 pm:
Is it possible to put cotton in his ears to muffle the noise and stall him so he can't see the fireworks if the cotton worked? EO
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Member:
Trigster
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Posted on Saturday, Jan 1, 2005 - 12:37 am:
I have a pole barn & the stalls are not completely enclosed because I live in south florida. Stalling him is the worst thing I can do for him. Makes him panic more. I tried that once and he reared up and tried to climb a 7 foot barrier. They go off right across the street from me so he can see them and feel them. They are so loud that cotton wouldn't do a thing. I try to move them out of here on the 4th of July and New Years if I can, but sometimes that doesn't always work out.
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Moderator:
DrO
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Posted on Saturday, Jan 1, 2005 - 9:23 am:
Absorption from oral use is variable and almost certainly dependent on recent feeding activity. However you do not need a number: you already have the information you need. The first results of toxicity are oversedation so if the horse is becoming more alert you can safely redose. This assumes your vet has approved this use, the horse is in good health, and does not have any unusual reactions to the medication.
DrO
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Member:
Eoeo
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Posted on Saturday, Jan 1, 2005 - 9:55 am:
Dr. O, I read the article on ace. However, I didn't understand how the timing was affected by ingestion of a meal. If given, does ace affect the digestion of a meal or it makes the effects last longer or not as long when the horse has ingested a meal? EO
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Moderator:
DrO
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Posted on Sunday, Jan 2, 2005 - 12:20 pm:
Food is likely to delay absorption so the drug is longer in the blood but peak blood concentration is less. That is the sedation will not be as profound but may last longer.
DrO
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Member:
Trigster
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Posted on Monday, Jan 3, 2005 - 8:42 pm:
Thanks Dr. O. Yes, vet has approved this use and he's in good health. Thanks for the additional info ref taking with or without food. I've wondered that also.
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