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Discussion on IV Oxytetracycline- administering
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Member:
teddyj1
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Posted on Monday, Nov 26, 2007 - 10:41 pm:
Hi Dr.O,
my gelding's going into his 9th day of IV OxyTet for his Lyme treatment.
Everything has been going very smoothly, but after reading the article on Tetracyclines I was curious.
I thought the reason we were using IV Oxytet was because oral Doxy was NOT well absorbed by horses, and there fore was not as effective at "clearing" the Borrelia infection, so I was wondering if this was different in the case of Lyme disease?
Secondly, I've been taking any where between 3-5 minutes to administer 35cc's of OxyTet, after first flushing with Heparin, followed by a second Heparin flush after the OxyTet, so now I'm wondering how fast is too fast when pushing the Oxytet thru the line, and next, I see that Heparin Sodium is Contraindicated??
Obviously I'm sure my Vet is very aware of these concerns, but I was wondering just how important these issues are, since they were not overtly explained at the beginning of treatment. Did I explain this well??
Just want to really understand as well as I can, since I am administering these potent drugs right to his jugular (:
Thank you !
TOD
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Moderator:
DrO
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Posted on Tuesday, Nov 27, 2007 - 6:40 am:
Doxycycline is absorbed orally but one small study showed it inferior, at the given doses in the experiment, of clearing an experimental infection when compared with tetracycline.
Giving a 35 cc injection over 5 minutes is giving it slow. I suspect the reason for the contraindication is that heparin binds ionized calcium (Ca2+). This would potentiate this toxic mechanism of tetracycline however the tiny amount used to flush a catheter may not be a problem.
DrO
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Member:
teddyj1
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Posted on Tuesday, Nov 27, 2007 - 9:34 am:
T H A N K Y O U ! 
Understood, and relieved
TOD
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