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  Discussion on Research Study: PSGAG Effect in Arthritis Model
Author Message
Moderator:
DrO

Posted on Thursday, Jul 22, 2010 - 7:48 am:

This is a interesting study supporting the use of PSGAG products in acute arthritis cases.
DrO

J Vet Pharmacol Ther. 2010 Aug 1;33(4):357-62.
Efficacy of intramuscular polysulfated glycosaminoglycan in a controlled study of equine carpitis.

Verde C, Ferrante M, Simpson MI, Babusci M, Broglia G, Landoni MF.

Cátedra de Farmacología, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, CONICET, La Plata, Argentina.

Abstract
Twelve healthy horses were subject to the monoioidoacetate (MIA) carpitis model, which was allowed to develop for 7 days. The horses were then randomly divided into two groups. Group A (control) received an intramuscular injection of normal saline every 4 days for a total of seven injections while group B received 500 mg of a PSGAG (SYNTEX CSY36) intramuscularly every 4 days for seven treatments. Efficacy of the PSGAG was evaluated by three clinical outcomes: lameness score, carpal circumference and maximum carpal flexion. Clinical outcomes were measured on days -8 (previous to carpitis induction), 0 (previous to drug treatment), 7, 14, 21, 28 and 35. Areas under the curve clinical outcome as function of time were built and used as variables for the statistical analysis. There was less joint circumference enlargement and lameness and greater carpal flexion in PSGAG-treated horses compared with that in controls. The studied compound has demonstrated to be efficacious on the treatment of a chemically induced carpitis in horses.
Member:
vickiann

Posted on Thursday, Jul 22, 2010 - 11:00 am:

Thanks for this information, Dr. O.
Member:
jones

Posted on Wednesday, Mar 30, 2011 - 12:48 am:

Just gave my "navicular" horse IM Adequan, 2nd shot. He is recovering from a neurectomy (2 weeks out) and I had not heard of using Adequan IM before. He had tildren and IA injections and I knew I wouldnt do IA shots (risk of infection, hassle, etc) with him so I didnt investigate Adequan further.
Prior to the nervectomy, with a posterior nerve block on the front right, he still landed on the lateral aspect of the toe and then rolled in, no head bob, just bad landing, when they did the right anterior digital nerve block he landed flat. He was sound on the left with the left posterior blocked. Both front posterior nerves were cut (they both looked bad on MRI) but consistent with the blocks he still landed on the lateral toe on the right.
10 days recovering from the neurectomy and I gave him his first IM Adequan injection and the RF landing looked better.
Second shot and I can hardly see the toe landing on the right. He is also on Previcox so I dont think the inflamation is what is being affected as the Previcox has been quite effective for him in all other ways. I guess the research on the Adequan site regarding IM efficacy verses IA injection can be considered biased but still it peaked my interest enough to try it. I will keep a post update but I hope they make a human form soon :-)
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