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Discussion on Research Summary: Loss of coordination with TMP/SMZ use
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Moderator:
DrO
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Posted on Monday, Dec 20, 2010 - 3:31 pm:
Though quite rare here is a report of possible ataxia in association with trimethoprim-sulphonamide use.
DrO
Equine Vet J. 2011 Jan;43(1):117-120.
Suspect novel adverse drug reactions to trimethoprim-sulphonamide combinations in horses: A case series.
Stack A, Schott .
Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, USA.
Abstract
Adverse drug reactions to trimethoprim-sulphonamide combinations are common in many species, manifesting as gastrointestinal tract disorders, dermatopathies and blood dyscrasias. In this case series, neurological abnormalities in 4 horses being treated with trimethoprim-sulphonamide combinations at normal dosages and in one foal that received an overdose are described. The horses developed hypermetric gait, agitation and erratic behaviour. All signs resolved once medication was withdrawn, and no horse had residual deficits. No other cause for observed neurological deficits could be determined. These clinical signs appear to represent a novel adverse drug reaction to some commonly used antimicrobial combinations.
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