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  Discussion on Research Summary: Acepromazine and Penile Paralysis
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DrO

Posted on Monday, Dec 20, 2010 - 3:51 pm:

Having seen this complication twice I would have pegged this complication as more frequent than found in this survey. In both the cases I saw the horse was debilitated, the amount of drug administered not clear, and initial treatment delayed. I will worry a bit less next time I ace a male to clean the sheath.
DrO

Equine Vet J. 2011 Jan;43(1):88-98.
Contemporary use of acepromazine in the anaesthetic management of male horses and ponies: A retrospective study and opinion poll.

Driessen B, Zarucco L, Kalir B, Bertolotti L.

Department of Clinical Studies, New Bolton Center, University of Pennsylvania, School of Veterinary Medicine, USA; University of California-Los Angeles, David Geffen School of Medicine, Department of Anesthesiology, USA; Dipartimento di Patologia Animale and Dipartimento di Produzioni Animali, Epidemiologia ed Ecologia, Facoltà di Medicina Veterinaria, Università degli Studi di Torino, Italy.
Abstract

Reason for performing study: Current use of acepromazine in the anaesthetic management of male horses and ponies and associated risks are largely unknown. Objectives: To explore anaesthetic acepromazine use and related adverse effects in the male horse. Methods: Of 8533 anaesthetised horses and ponies medical records of male animals treated perianaesthetically with acepromazine were reviewed. Demographic data, time and dose of acepromazine administration, co-administered drugs, quality of induction and recovery from anaesthesia, arterial blood pressures, and occurrence of penile dysfunction were recorded. Practising ACVA and ECVAA diplomates were polled on the use of acepromazine and its effects on blood pressure and penile dysfunction in the equine. Results: Of all animals, 12% females and 11% males (n = 575 including 42% stallions) received perianaesthetic acepromazine, predominantly for premedication. Anaesthetic induction was smooth in 566 animals. Lowest mean arterial pressures averaged 65 ± 9 mmHg. Recovery was good or very good in 70% of all animals and 74% stood after 1-2 attempts. In 14 horses (2.4%; 7 stallions, 7 geldings), penile prolapse occurred for 0.5-4 h and in one stallion (0.2%) for >12 but <18 h>12 h and only one recalls 3 cases of irreversible penile prolapse in 20 years of anaesthesia practice. Conclusions and potential relevance: The extremely low risk of permanent penile dysfunction (≤1 in 10,000 cases) does not justify more restricted use of acepromazine in the intact male vs. geldings and mares.
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