Site Menu:
| This is an archived Horseadvice.com Discussion. The parent article and menus are available on the navigation menu below: |
| HorseAdvice.com » Training & Conditioning Horses » Musculoskeletal Conditioning » Exercise Physiology and Conditioning » |
| Discussion on Reseach Summary: Milk Basic Protein and Bone Metabolism | |
| Author | Message |
| Moderator: DrO |
Posted on Monday, Apr 9, 2007 - 10:51 am: The protein extract from milk has been shown to have beneficial effects on bone health in humans above what would be expected from just its amino acid make up. Can we expect help from milk basic protein with the bone problems encountered in young performance horses. The following work suggests so.DrO Equine Vet J Suppl. 2006 Aug;(36):654-8. The effect of milk basic protein supplementation on bone metabolism during training of young thoroughbred racehorses. Inoue Y, Asai Y, Tomita M, Kuribara K, Kobayashi M, Kaneko M, Toba Y. Equine Science Division, Hidaka Training and Research Center, Japan Racing Association, 535-13, Aza-Nishicha, Urakawa-cho, Urakawa- gun, Hokkaido, Japan. REASONS FOR PERFORMING STUDY: In laboratory animals, man and cell culture experiments, milk basic protein was reported to suppress bone resorption and promote bone formation. However, no studies in horses have previously examined the effect of milk basic protein. OBJECTIVES: To evaluate the effect of milk basic protein supplementation on bone metabolism in young Thoroughbred horses in training. METHODS: Twenty 2-year-old horses in training were used for 90 days in this study. The treatment group was fed a basal diet with 1 g of milk basic protein and the control group a basal diet only. Blood samples were collected on Days 0, 45 and 90 to determine serum calcium (Ca) and biochemical markers of bone metabolism. Radiographs were taken at the start and end of the study to determine radiographic bone aluminium equivalence (RBAE). RESULTS: Serum osteocalcin (OC) was significantly higher at Day 45 after the beginning of the study in the treatment group compared to that in the control group. The treatment group showed a greater increase in the total RBAE change at the end of this study compared to that in the control group. However, there were no significant differences in serum Ca and carboxy-terminal telopeptide of type I collagen (ICTP) between groups. CONCLUSIONS AND POTENTIAL RELEVANCE: These findings provide preliminary evidence that milk basic protein has an effect on bone formation in 2-year-old Thoroughbred horses in training. However, further studies in larger groups of horses are now required to substantiate our findings. |
| Member: sunny66 |
Posted on Tuesday, Apr 10, 2007 - 2:15 pm: Dr. O, or anyone...where would one find a supplement for this? I know the study didn't focus on older horses, but if it helps the younger ones I want to give it a go.This is all I could find: GlutaSyn®, a breakthrough milk serum isolate patented for support of immune response and the fundamental antioxidant, glutathione (GSH). |
| Member: sunny66 |
Posted on Tuesday, Apr 10, 2007 - 3:58 pm: Found one, what do you think Dr. O?https://www.enduracal.com/ EnduraCal27 provides benefits all through an equine athlete’s life. Helps reduce bone injuries. Helps accelerate bone development and healing. EnduraCal27 is also ideal for: Foals after weaning. Yearlings in training. Pregnant or lactating mares. EnduraCal27 is formulated to: Get thoroughbreds back to the track sooner. Accelerate healing of breaks and fractures. Strengthen the bones of young horses. EnduraCal27 helps to: Regulate cellular level activities in equine bone. Maintain a regulated blood calciummineral nutrition level. Provide a balanced nutrient profile to help mineral absorption for building and maintaining strong, healthy bones. Active Ingredient: DariCal™ Milk Mineral Complex extracted from milk, contains essential bone mineral nutrients such as Calcium, Phosphorus, Magnesium, Potassium, Iron, Zinc, Copper, Manganese and other micro minerals, Vitamin D2, Vitamin K1, Milk Serum Basic Proteins, Carbohydrates and Fatty Acids in a bioavailable form for easy absorption and assimilation to help promote bone formation and maintain bone health. Serving Size Amount/Serving Calories 70 Calories from Fat less than 4g Total Fat less than .57g Saturated Fat less than 0g Cholesterol 0g Sodium 115mg Potassium 285mg Total Carbohydrate 2.3g Sugar 0g Fiber 0g Protein .35g Calcium 7.4g Vitamin D 2960iu Vitamin K 45mcg Iron 7.25mg Phosphorus 4.25g Magnesium 567mg Zinc 4.25mg Manganese 0.425mg Copper 0.454mg Milk Serum Basic Proteins .749mg Fatty Acids 1.42g Carbohydrate 2.3g Pat. 5639501 . Additional patents pending. |
| Member: kamibroo |
Posted on Wednesday, Apr 11, 2007 - 1:33 am: I had been recently looking at Whey Protein, but somehow, I doubt that is the same as "milk basic protein" ?It would be interesting to know the source or what they used for "milk basic protein". By this statement, are they saying that the protein was not also providing a significant source of calcium? Did anything in the study evaluate brittleness? Kami |
| Moderator: DrO |
Posted on Wednesday, Apr 11, 2007 - 7:33 am: From my reading whey contains MBP USHO but I have not found a concentration. Aileen, the research does not support, or even suggest, this may be a treatment for lameness.DrO |
| Member: sunny66 |
Posted on Wednesday, Apr 11, 2007 - 10:24 am: Thanks Dr. O, I do realize it's not a treatment for lameness, but if it may help further bone degeneration, I want to try it. He turns 14 on April 15... he had so much bone deterioration in two years, I want to see if I can at least slow it down a little...The link above states that supplement: Helps reduce bone injuries. Helps accelerate bone development and healing. USHO, I'm hoping that it does help with brittleness, that's why I want to try it... |
| Member: kamibroo |
Posted on Thursday, Apr 12, 2007 - 11:35 pm: Aileen,I'm not sure who "he" is that turns 14 or they type of bone deterioration that you're experiencing (bone loss, arthritis, ??). From the web site's look, I think by "bone injury" they may be referring to chips and factures in high performance horses. If you're having rapid visible bone deterioration, has your vet suggested a cause? I know some things in excess can lead to brittle bones. Long term excess Vit A is routinely suggested to do this, but I haven't found a study to support that specific toxic response. I can't remember the other things off the top of my head, but many things also interfer with the calcium needed to maintain bones. Have you done an analysis of ALL of his food sources? If you haven't already done a complete nutrition work up (or found someone to do that), I would be hesitant to add anything more unless you absolutely know that the bone deterioration is not from a nutritional imbalance. I know there are people who specialize in this and even a paid nutritionist might be less than a 3 months supply of the product at the listed link. Balancing everything is hard enough with just a hay source and complete feed. The more supplements you add, the more complicated it gets. This site is a great start for the basic requirements and how many things interact (like Ca:P) so need to be balanced. As an example: In the product you listed above it provides Vit D (a fat soluable vit). A horse on 24/7 turnout probably creates enough Vit D from the sunlight exposure since its estimated that only 6hrs sunlight is needed to meet basic vit D needs (can't remember the source). From this site under "Vitamins and Horses" it says "vitamin D excess will cause bone abnormalities" (not meant to imply that this applies to your situation and you should read the rest yourself). I'm only pointing out this one item because I recognized Vit D as a fat soluable vitamin and to show how supplements can get you out of balance or into a toxic sutation real easy if you don't add ALL of them up together w/your basic feeds and your hays/pasture to see what you're actually feeding. I was looking at Whey because of specific forms of protien found in it (not the calcium/bone issue). I'm interested in bone density (loss and building) because of a racing TB. There are many products that claim to make horses faster, stronger, brighter, calmer, etc, etc... you really need to look beyond the sales pitch to see what the ingredients are and the nutritional analysis once its added to everything you have now. I'm sorry to hear that your boy is having such a serious issue. I hope you find an answer for him soon. Kami |
| Moderator: DrO |
Posted on Friday, Apr 13, 2007 - 6:56 am: Aileen, concerning the product I do not know of any evidence that such a product will accelerate bone healing on a horse receiving an already balanced diet nor slow down degeneration is the case of osteoarthritis and do not advise its use for such a purpose.DrO |
| Member: sunny66 |
Posted on Friday, Apr 13, 2007 - 10:18 am: Thanks Dr. O, I will not purchase it Thank you Kami "He" is on my profile, my heart horse He has bony changes in pastern, hocks and stifles. For a while he was getting a lot of different supplements, he still is but not as much... I do pass everything through my vet to ensure his diet is balanced. Interesting about the Vitamin D causing bone abnormalities, I will look closer at this ... I've been a member here for years now and I'm STILL learning something new daily I truly appreciate your thoughtful post! |
| Member: kamibroo |
Posted on Friday, Apr 13, 2007 - 12:42 pm: Just a quick note. I don't think the Vit D is related to your issues, just was pointing out one of those additives that can get unbalanced.My vet doesn't do nutrition. If I ask about a supplement, he'll give an opinion or tell me if he's seen others have success. That isn't the same as doing their whole nutrition profile. That takes some time and you would have to give him information about all your feed stuff. There's really no way to do it in your head. My feed guy (degree in equine nutrition) got me started. I know Southern States have nutritionist that you can work with. Obviously they want you to use their feed, but I like their feed. There are independent people who focus only on that. You could try asking at www.safergrass.org for a referral to a nutritionist. I've read several people who said that just getting the diet balanced did wonders for their horses conditions. So I think it is really worth it. I come from a background of working with horses that have various problems. They usually came to me free instead of being euthanized. Some came in with a grocery list of supplements that they were getting. Once I got rid of that stuff and balanced their diet, everyone of them improved. So I'm a big believer in getting the fundamentals right before going into the fancy stuff. Good luck with your guy. Kami |
| Member: sunny66 |
Posted on Friday, Apr 13, 2007 - 3:51 pm: Thanks Kami It seems no one tests their hay anymore around here, I will look into the safergrass link. He currently gets: 8 lbs of timothy hay 4 cups daily of grass hay pellets in the pasture pal (mostly because he gets so little hay (ie FAT) this keeps him occupied for longer - tendency toward ulcers) 1 pound LMF Super Supplement (basic supplement) Farrier's Formula (hoof issues) Quiessence (magnesium deficient) Cosequin (DJD) Conquer (DJD) Vitamin E (hopefully to help his immune system due to a low white blood cell count, but I may rethink this one based on his chemistry panel taken next week) Adequan once a month (djd) I do try to keep it simple... he just isn't helping... lol... btw, you're a welcome addition to HA
|
| Member: mrose |
Posted on Sunday, Apr 29, 2007 - 1:04 am: I was just reading through their catalog, and just FYI Platinum Performance makes Equi-Whey which is a lactose free 75% whey protein concentrate. The product "blurb" says it's "an easily absorbed and digested complete protein which contains all of the essential amino acids and has the highest biological value of any protein source" Also, that it contains "more branched-chain amino acids" critical for muscle growth and development "than anyother protein source." "rich in Glutamine and helps support healthy immune function by increasing the endogenous antioxidant glutathione Peroxidase." The manufacturers suggest this product for horses in stress and high performance.Libby was sent home with Platinum Performance Equine, Ortho-Chon, and Osteon to help strengthen and increase the density of her bone in her injured leg. |
| Moderator: DrO |
Posted on Sunday, Apr 29, 2007 - 9:00 am: Thanks Sara,The use for bone enhancement is very interesting. I do have a problem with the manufacturer's recommendation however. In general high performance horses, while consuming enough food to maintain energy balance, often consume excessive amounts of protein and it is hard to imagine a scenario that would need a protein supplement. A product like this would be a blessing for folks who have poor quality forage or very easy keepers on energy limited diets. They can get their protein and limited energy to. How much does the product cost per lb Sara and what is the guaranteed analysis? DrO |
| Member: mrose |
Posted on Sunday, Apr 29, 2007 - 10:52 am: Equi-Whey- Heavy training and performance, 144g 2x/day; racehorses and Grand Prix jumpers - 144g 2x/day; endurance and western performance horses - 72g ex/day. (I find in interesting they put these two in the same class; I wouldn't.)Info in booklet only says "Lactose Free 75% Whey Protein Concentrate." Platinum Performance Equine - 66g./day. More for horses under a lot of stress or in heavy work (1 to 3x as much, depending on work/stress, and examples are given. Contains: Flax seed, flax oil, rice bran, whey protein, sunflower seed, soy flour, can molasses, minerals, bio-sponge, vit.E (el-alpha-tocopheryl acetate) vit.C (ascorbic acid) Glucosamine sulfate, natural vit. E (d-Alpha tocopheryl Acetate) Chromium, yeast, selenium yeast, pine bark, aloe vera, docosahexaenoic acid, calcium carbonate, taurine, L-carnitine, vit. A., choline bitartrate, niacin, vit.K, calcium pantothenate, riboflavin, vit. B-12, thiamin, pyridoxine hyDrOchloride, folic acid, biotin, natural flavors. No artificail flavors or perservatives. guaranteed analysis: Per 132g KCAL/# (Therms) 654kcal Carbohydrate 42.25g Crude Protein 23.75g Crude Fat 37.6g Crude Fiber 11.9g Ash 15.85g Linolenic Acid 14.5g Docosahexanoic Acid 132mg Linoleic Acid 7.9g Amino Acids Arginine 1980mg Glycine 1188mg Methionine 163mg Isoleucine 924mg Leucine 1188mg Valine 1056mg Lysine 250mg Tyrosine 528mg Cystine 264mg Glutamine 4356mg Phenylalanine 1056mg Threonine 792mg Aspartic Acid 792mg Alanine 2112mg Histidine 924mg Tryptophan 528mg L-Carnitine 5mg Proline 600mg Trace Minerals Boron .6mg Chromium 0.25mg Cobalt 0.25mg Copper 13mg Iron 264mg Manganese 13mg Selenium 0.25mg Silicon 2640mg Sulfur 475mg Zinc 25mg Iodine .13mg Electrolytes Phosphorus 1060mg Calcium 530mg Magnesium 540mg Potassium 1320mg Sodium max 265mg Sodium min 130mg Vitamins Vitamin A 2500IU Vitamin C 250mg Vitamin E 250IU Vitamin D 500IU Vitamin K 1.1mg Folic Acid 2.5mg Thiamin 13.2mg Riboflavin 11mg Niacin 13mg Choline 6mg Pyridoxine 13mg Cyanocobalamin 44mcg Pantothenic Acid 22mg Biotin 2.5mg ChonDrOprotective Glucosimine sulfate 850 mg. (net Glucosimine 500 mg.) 10 lbs. (69 servings)$50.00 17.5 lbs. (120 sevings) $88 25 lbs. (171 servings) $125 Ortho-Chon: "Ortho-Chon Equine is a potent joint protective formula, designed to support healthy joint function. Ortho-Chon contains Glucosamine Sulfate, MSM and specific herbs and antioxidants to help protect cartilage from free radical damage. Ortho-Chon is most effective when used in conjunction with Platinum Performance Equine Formula, because of the beneficial effects of the Omega-3 Essential Fatty Acids in Platinum Performance Equine." ingredients Glucosamine Sulfate, Methylsulfonylmethane (OptiMSM), Boswellia Serrata extract, Harpagophytum Procumbens (Devil's Claw), Cetyl-Myristoleate, Vitamin C (Ascorbic Acid), and Uncaria Tomentosa (Cat's Claw). dosage: 1 Tablespoon (10,000mg.) 2x/day or as reccommended by your vet. 1.13 lbs. (58 servings $55 4 lbs. (181 servings $152 Osteon Natural Source of Silicon Silicon is an essential trace element that is important in the formation of articular cartilage and connective tissue. Silicon is an integral component of Glycosaminoglycans, such as ChonDrOitin Sulfate and Hyaluronic Acid and is an essential element for proper bone formation and calcification. Zeolite contains more than 60% silicon. Silicon supplementation along with Omega-3 Essential Fatty Acids, amino acids, antioxidants and minerals are beneficial for good bone and cartilage development. } dosage: 90g. 2x/day for 1000lb horse 10 lbs. (50 servings) $39 25 lbs. (126 servings) $77 You can go to the website https://platinumperformance.com for more info. |
Horseadvice.com
is The Horseman's Advisor
Helping Thousands of Equestrians, Farriers, and Veterinarians Every Day
All rights reserved, © 1997 -
is The Horseman's Advisor
Helping Thousands of Equestrians, Farriers, and Veterinarians Every Day
All rights reserved, © 1997 -
