Clinical effects of a combination of phenylbutazone and omeprazole

Clinical effects of a combination of phenylbutazone and omeprazole on chronic lameness in Mongolian horses
Equine Vet J. 2023 Jun 19.
Authors
Zhengyi Li 1 , Shan Du 1 , Xiaomin Wang 2 , Lanxin Zhang 1 , Xinyu Liu 1 , Quanrong Fan 1 , Huidi Yang 3 , Ruifeng Gao 1
Affiliations

1 College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, China.
2 Agriculture and Animal Husbandry Bureau, Karaqin Banner, Chifeng, China.
3 College of Basic Medicine, Inner Mongolia Medical University, Hohhot, China.

PMID: 37337455
DOI: 10.1111/evj.13962

Abstract

Background: Phenylbutazone (PBZ) is the most commonly used drug to treat symptoms of lameness in horses; however, it is associated with adverse effects such as gastric ulcer syndrome (EGUS). Interestingly, many practitioners prescribe omeprazole (OME) concurrently with PBZ to prevent the development of EGUS. However, the efficacy and safety of this practice in Mongolian horses with chronic lameness remain unknown.

Objectives: To evaluate the clinical effects of a combination of PBZ and OME on chronic lameness in Mongolian horses.

Study design: Randomised block experimental design.

Methods: Eighteen Mongolian horses with lameness score was ≥3 points, were divided into three treatment groups, with six horses in each group: placebo (CON), PBZ (4.4 mg/kg PO q. 24 h), or PBZ plus OME (4 mg/kg PO q. 24 h; PBZ + OME) in a randomised block design based on the initial lameness score. The horses were treated for 15 days. During this period, weekly gastroscopy, and physiological and biochemical tests were performed.

Results: Both PBZ (median 1.0, interquartile range [IQR]: 0.8-1.3; p = 0.01) and PBZ + OME (median 1.0, IQR: 1.0-1.0; p = 0.01) significantly decreased the lameness score compared with before administration. In addition, PBZ significantly increased the equine glandular gastric disease (EGGD) score (3.0 ± 0.6, p < 0.001), GT-17 content (293.4 ± 21.8 pg/mL, p < 0.001), and pepsinogen-1 (PG1) content (295.3 ± 38.3 ng/mL, p < 0.001) compared with CON or PBZ + OME. However, it significantly reduced the total protein (53.6 ± 1.5 g/L, p < 0.05) and albumin (25.5 ± 1.8 g/L, p < 0.05) contents. Nevertheless, compared with PBZ, PBZ + OME significantly decreased the EGGD score (0.3 ± 0.5, p < 0.001) and significantly increased the gastric fluid pH (7.3 ± 0.5, p < 0.001), total protein content (62.5 ± 4.6 g/L, p = 0.009), and albumin content (29.4 ± 1.1 g/L, p = 0.004). Meanwhile, they significantly diminished the gastrin 17 (GT-17) (162.0 ± 21.0 pg/mL, p < 0.001) and PG1 (182.4 ± 22.5 ng/mL, p < 0.001) contents. Main limitations: Individual differences in horses were larger, but the sample size was small. There was larger interval between observations for each index. Conclusions: Compared with PBZ alone, PBZ + OME had no therapeutic effect on chronic lameness; however, it reduced the occurrence of EGGD in Mongolian horses. Horses may be protected against chronic lameness and PBZ-induced EGGD by increasing the pH value, decreasing serum PG1 and GT-17 content, and preventing the reduction of myeloperoxidase content. Keywords: Mongolian horses; chronic lameness; equine gastric ulcer syndrome; horse; omeprazole; phenylbutazone. 00000