Effect of Pg F2 α administration on uterine PMN count

An interesting study in treating chronic noninfectious endometritis but it is promising. An injection of PgF2a on the day of ovulation decreased neutrophil count. It remains to be seen if this will increase pregnancy rates in this group of mares but that should be the next study.
DrO

Effect of prostaglandin F2 α administration on uterine polymorphonuclear neutrophil counts in Japanese heavy draft horses
J Equine Sci. 2021 Dec;32(4):117-124.
Authors
Tadamasa Niikura 1 2 , Munkhtuul Tsogtgerel 3 2 , Chizuru Niikura 1 , Haruna Wada 1 , Seiya Kanzawa 1 , Takashi Fujiwara 1 , Yasuo Nambo 3 2
Affiliations

1 Hokubu Veterinary Clinical Center, Tokachi Agricultural Mutual Aid Association, Ashoro 089-3708, Japan.
2 Department of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido 080-8555, Japan.
3 United Graduate School of Veterinary Sciences, Gifu University, Gifu 501-1193, Japan.

Abstract

The objective of this study was to examine the effect of prostaglandin F2α (dinoprost) and oxytocin administration on uterine polymorphonuclear neutrophil counts in the Japanese heavy draft mare. To compare polymorphonuclear neutrophil (PMN) counts in the endometrium, a total of 162 samples were collected from 54 estruses of 47 mares (before ovulation, day 0, and day 2) using a double-guarded cytology brush. Dinoprost (PG; 5 mg) was administered intramuscularly (i.m.) only once, on day 0, whereas oxytocin (OT; 20 U i.m.) was administered three times at 12-hr intervals starting on day 0. The plasma progesterone concentrations from days 0 to 14 were not different between the non-treatment (CON), PG treatment, and OT treatment groups. The PMN counts increased in all the groups from before administration to day 0 (CON, 0.90 to 3.55; PG, 1.20 to 8.45; and OT, 0.70 to 1.70; P=0.0014, 0.0046, and 0.0073, respectively). There was a significant decrease in PMNs from day 0 to day 2 only in the PG group (P=0.0073). The pregnancy rate was not different among the CON (12/18), PG (14/18), and OT (10/18) groups. The results of this study indicate that dinoprost can reduce uterine polymorphonuclear neutrophil counts.

Keywords: dinoprost; endometritis; heavy draft horse; polymorphonuclear neutrophil.