Effects of ketoprofen and phenylbutazone on chronic hoof pain and lameness

Studies suggest that the increased dose of ketoprofen studied below should not increase the adverse effects substantially.
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Effects of ketoprofen and phenylbutazone on chronic hoof pain and lameness in the horse

Equine Vet J. 1995 Jul;27(4):296-300. doi: 10.1111/j.2042-3306.1995.tb03080.x.
J G Owens 1, S G Kamerling, S R Stanton, M L Keowen
Affiliations expand
PMID: 8536666 DOI: 10.1111/j.2042-3306.1995.tb03080.x
Abstract
The analgesic effects of the nonsteroidal anti-inflammatory drugs, ketoprofen (2.2 and 3.63 mg/kg bwt) and phenylbutazone (4.4 mg/kg bwt) were compared in 7 horses with chronic laminitis. Hoof pain was quantified objectively by means of an electronic hoof tester and lameness was subjectively graded on a modified Obel scale. Ketoprofen at a dose of 3.63 mg/kg bwt (phenylbutazone equimolar dose) reduced hoof pain and lameness to a greater extent than the 2.2 mg/kg dose and phenylbutazone. These effects were still present at 24 h in 3 of the 4 pain tests, including lameness grade. These data suggest that ketoprofen at the dosage rate of 1.65 times the recommended therapeutic dose was more potent than phenylbutazone in alleviating chronic pain and lameness in horses.