Glutathione peroxidase in horses supplemented with vitamin E and selenium

Whole blood glutathione peroxidase activity in Standardbred broodmares supplemented with vitamin E and selenium

Can J Vet Res. 2026 Jan 1;90(1):25-29. eCollection 2026 Jan.
Authors
John D Baird 1 , Luis G Arroyo 1 , John H Lumsden 1
Affiliation

1 Department of Clinical Studies (Baird, Arroyo) and Department of Pathobiology (Lumsden), Ontario Veterinary College, University of Guelph, 50 Stone Road East, Guelph, Ontario N1G 2W1.

PMID: 41585003
PMCID: PMC12825818

Abstract
in English, French

The objective of this study was to determine the effect of either oral supplementation of sodium selenite and alpha-tocopherol or intramuscular administration of a commercial preparation of selenium (Se) and vitamin E to Standardbred broodmares with low (21.0 ± 18.1 IU/g Hb) whole blood glutathione peroxidase (GPx) activity. Ten mares received 3 weekly intramuscular (IM) doses, whereas 9 mares were orally supplemented daily for 10 wk. Blood samples were collected via jugular venipuncture and the whole blood GPx activity was measured at each sampling time for the 32-week period. Both oral and intramuscular administration resulted in a marked increase in whole blood GPx activity in both groups of mares.

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