Antibiotic for treating resistant gram negative infections. Though not currently approved for other than intrauterine use in horses, it has gained wide spread use in foal septicemia, and anywhere resistant gram negative infections occur. This article is about the contraindications, toxic effects, dosages, and association drug rules that apply to this medication.

Amikacin occurs as a white, crystalline powder that is sparingly soluble in water. The commercial injection is a clear to straw-colored solution and the pH is adjusted to 3.5 - 5.5 with sulfuric acid. Amikacin sulfate for injection should be stored at room temperature (15-30?C); freezing or temperatures above 40?C should be avoided. Solutions may slightly yellow with time, but this does not indicate a loss of potency. Amikacin is stable for two years at room temperature. In vitro inactivation of aminoglycoside antibiotics by penicillin family of drugs and the other beta-lactam antibiotics is well documented. While amikacin is less susceptible to this effect, it is usually recommended to avoid mixing these compounds together.