Cyproheptadine

Cyproheptadine Use in the Horse

by Robert N. Oglesby DVM

Introduction

Introduction » Pharmacology » Safety » Adverse Effects » Drug Interactions » Dosage » Monitoring Parameters » Availability » More Info & Discussions

Cyproheptidine is a antihistamine that also has serotonin antagonist properties in the CNS. In horses and equines it has been useful for several unrelated horse issues including photic head shaking and Cushinoid disease of horses. This article describes its pharmacology, safety, and dosage in the horse and provides links to disease where it is use has been advocated in horses.

Pharmacology

Introduction » Pharmacology » Safety » Adverse Effects » Drug Interactions » Dosage » Monitoring Parameters » Availability » More Info & Discussions

Cyproheptadine is poorly studied in horses. Cyproheptadine acts like most antihistamines by competing for H1-receptor sites on cells. Antihistamines do not block histamine release. Cyproheptadine has significant antiserotonin activity and may have calcium channel blocking action as well. In other species it is well absorbed after oral administration but it's distribution is not well described. Probably metabolized in the liver with the metabolites excreted in the urine. Elimination is reduced in renal failure.

Safety

Introduction » Pharmacology » Safety » Adverse Effects » Drug Interactions » Dosage » Monitoring Parameters » Availability » More Info & Discussions

                       
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