Clinical responses in horses and ponies treated with canagliflozin

Short-term clinical responses in horses and ponies treated with canagliflozin: A clinical field study

Equine Vet J. 2026 May 10. doi: 10.1002/evj.70181. Online ahead of print.
Authors
Moa Hällbom 1 , Sanna Truelsen Lindåse 2 , Monika Wartel 1 , Johan Bröjer 2
Affiliations

1 Distriktsveterinärerna, The Swedish Board of Agricultural Science, Fjärdhundra, Sweden.
2 Department of Clinical Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden.

PMID: 42108673
DOI: 10.1002/evj.70181

Abstract

Background: Treatment with the sodium-glucose co-transporter 2 (SGLT2) inhibitor canagliflozin in insulin dysregulated (ID) horses has shown promising results in randomised clinical trials. Larger field studies are needed to further evaluate treatment responses and potential adverse effects under real-world conditions.

Objectives: To assess the short-term effects of canagliflozin on postprandial glucose and insulin responses in client-owned horses and ponies with ID using a single-sample feed-challenge test (FCT), and to characterise treatment-associated changes in bodyweight, liver enzyme activities, and triglyceride concentrations.

Study design: Multicentre pre-post intervention study.

Methods: Seventy privately owned horses and ponies with ID, confirmed by an oral sugar test, were enrolled. Horses received oral canagliflozin (0.4-0.6 mg/kg bwt once daily) for 3 weeks. Bodyweight, clinical biochemical parameters, and glucose and insulin concentrations from an FCT based on each horse’s forage were obtained before and after treatment. Data were analysed using linear mixed-effects models.

Results: The least squares (LS) means insulin concentrations (± SEM) during the FCT decreased from 304.4 ± 25.4 to 171.2 ± 25.9 μIU/mL after 3 weeks of treatment with canagliflozin (p < 0.001). Thirteen percent (9/70) of horses did not exhibit a reduction in insulin concentrations after treatment. The geometric LS means (95% confidence interval) triglyceride concentration (0.4 [0.3-0.5] vs. 1.2 [0.9-1.5] mmol/L; p < 0.001) and glutamate dehydrogenase (GLDH) activity (91 [73-112] vs. 152 [123-188] μkat/L; p < 0.001) increased with treatment. Hyperlipaemia-range triglyceride concentrations (>5.6 mmol/L) were observed in 9% (6/70) of treated horses.

Main limitations: Absence of a placebo-treated control group.

Conclusions: The postprandial insulin concentrations decreased in most canagliflozin treated horses, however, a subset failed to respond or developed marked increases in triglycerides. These findings underscore the need for careful monitoring of insulin response and lipid parameters during SGLT2 inhibitor therapy in horses.

Keywords: SGLT2 inhibitors; canagliflozin; horse; hyperinsulinemia; insulin dysregulation.

© 2026 The Author(s). Equine Veterinary Journal published by John Wiley & Sons Ltd on behalf of EVJ Ltd.

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