Detomidine Oromucosal Gel for Alleviation of Acute Anxiety

No this would not be suitable to ease a riding horse but good to know on New Years Eve and the 4th of July. I have known several field trial and field hunter riders that gave their horses 1 – 2 ml ace IM an hour before the competition, this is still not a recommended practice.
DrO

Use of Detomidine Oromucosal Gel for Alleviation of Acute Anxiety and Fear in Horses: A Pilot Study
Front Vet Sci. 2020 Oct 20;7:573309.

Authors
Francesca Dai 1 , Julia Rausk 2 , John Aspegren 3 , Mirja Huhtinen 3 , Simona Cannas 1 , Michela Minero 1
Affiliations
1 Dipartimento di Medicina Veterinaria, Università degli Studi di Milano, Milan, Italy.
2 Institute of Veterinary Medicine and Animal Sciences, Estonian University of Life Sciences, Tartu, Estonia.
3 Orion Corporation, Orion Pharma, R&D, Espoo, Finland.

Abstract

The aim of this randomized, double-blind, placebo-controlled, parallel group clinical field study was to evaluate the effect of detomidine oromucosal gel in alleviating anxiety and fear in horses. Sixteen horses with a history of acute anxiety and fear associated with firework-related noise entered the study. On New Year’s Eve, eight horses were treated with 30 μg/kg detomidine gel and eight horses with placebo gel. When fireworks were present, 75% (6/8) of the detomidine-treated horses were scored by their owners as having a good or excellent treatment effect on anxiety and fear, while 50% (3/6) of horses receiving placebo were scored to have a good effect. Horses’ behavior was video-recorded and assessed with a focal animal continuous method by a treatment-blind expert observer. Results showed that when fireworks were present, walking behavior decreased significantly (p < 0.05) after treatment with detomidine and that horses of the placebo group, overall, showed more restlessness, vocalization, and signs of colic (Wilcoxon matched-pairs test on the first PC, p = 0.007). This study indicates that detomidine oromucosal gel can be used to alleviate acute noise-related anxiety and fear in horses, but larger treatment groups are needed to confirm the results.