Evaluation of a Chinese herbal supplement on gastric ulcers

J Vet Intern Med. 2019 Aug 23.
Evaluation of a Chinese herbal supplement on equine squamous gastric disease and gastric fluid pH in mares.
Munsterman AS1, Dias Moreira AS2, Marqués FJ2.

Author information:
1. Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin.
2. Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin.
Abstract
BACKGROUND:
Wei Le San (WLS) is a Chinese herbal formula comprised of 9 herbs selected for their putative anti-inflammatory effects.
OBJECTIVES:
To evaluate the effects of WLS administration in horses with nonglandular gastric ulcers.
ANIMALS:
Ten mixed breed mares (aged 7-21 years, 401-567 kg body weight).
METHODS:
Experimental design was a blinded, prospective, 2-period crossover study. All horses received a placebo (25 mL dextrose-based syrup; n = 10) and the treatment (WLS, 5 g in 25 mL dextrose-based syrup; n = 10), administered twice daily. Horses underwent a 1-week, alternating feed-deprivation period to induce or worsen existing ulcers; treatment began on day 7. Gastroscopic examination was performed on d0, d6, and d35, with gastric fluid pH obtained on d6 and d35. Gastric ulcer scores assigned by 3 masked observers were averaged for each examination.
RESULTS:
Ulcer number scores for horses treated with WLS (median = 0; range, 0-4) was not different from the untreated controls (median = 0.5; range, 0-4; P = .81) by the end of the treatment period. Ulcer severity score for treated horses (median = 0; range, 0-1) was also unchanged compared to the control group (median = 0.5; range, 0-1; P = .85). Gastric pH was not altered by either treatment, with a median of 2.1 (range, 1.9-4.1) for the horses treated with WLS and 2.8 (range, 1.6-7.2) in the untreated controls (P = .46).
CONCLUSIONS AND CLINICAL IMPORTANCE:
The experimental model used to induce gastric ulceration was unable to discern a difference between the herbal supplement and the placebo in normal horses.